Integrating mitochondrial translation into the cellular context. Nat. Rev. Mol. Cell Biol. 16, 586-592.Richter-Dennerlein, R., Dennerlein, S., and Rehling, P. (2015). Integrating mitochondrial translation into the cellular context. Nat Rev Mol Cell Biol 16, 586-592....
In this review, we summarize the process of human mitochondrial translation and delineate its upstream and downstream regulatory mechanisms. Importantly, we provide a comprehensive overview of the impacts of mitochondrial translation on normal and malignant hematopoiesis. Furthermore, this review outlines th...
The evolution of mitochondria has proceeded independently in different eukaryotic lines, which is reflected in the diversity of mitochondrial genomes and m
Objective: To investigate the relationship between mitochondrial translation elongation factors Tu and Ts (EF-Tu mt, EF-Ts mt) and status epilepticus in rats. 方法:建立大鼠癫痫持续状态模型 ,应用免疫组织化学法观察在癫痫发作时 ,大脑皮质、海马和纹状体中线粒体蛋白质翻译延长因子Tu和Ts表达的变化。2...
In this review we describe the proteins orchestrating mitochondrial translation initiation: bacterial-like general initiation factors mIF2 and mIF3, as well as mitochondria-specific components – mRNA-specific translational activators and mRNA-nonspecific accessory initiation factors. We consider how the ...
Here we show that loss of the catalytic activity of the mitochondrial folate enzyme serine hydroxymethyltransferase 2 (SHMT2), but not of other folate enzymes, leads to defective oxidative phosphorylation in human cells due to impaired mitochondrial translation. We find that SHMT2, presumably by ...
摘要: For a long period of time, the functional properties and the very existence of mitochondrial translation in trypanosomatids remained controversial. The unusual resistance of the system to the known...关键词: Cryo-electron microscopy Leishmania tarentolae Mitochondrial translation Mitoribosome ...
Mitochondrial translation is necessary for the generation of thirteen respiratory complex subunits. mt-mRNAs are unique in that they are uncapped, have no or very few 5’-untranslated nucleotides, and contain a poly A tail that immediately follows or forms part of the stop codon[4]. The mito...
A. Mitochondrial respiratory-chain diseases. N. Engl. J. Med. 348, 2656–2668 (2003). Article CAS PubMed Google Scholar Boczonadi, V. & Horvath, R. Mitochondria: impaired mitochondrial translation in human disease. Int. J. Biochem. Cell Biol. 48, 77–84 (2014). Article CAS PubMed ...
mitochondrial translation initiation factor 3 LSU: large subunit NC: normal chow NTD: N-terminal domain NTE: N-terminal extension PA: physically active PD: Parkinson’s disease SED: sedentary SSU: small subunit TACO1: translational activator of cytochromecoxidase 1 ...