Caseinolytic peptidase P (ClpP) is a mammalian quality control protease that is proposed to play an important role in the initiation of the mitochondrial unfolded protein response (UPR mt ), a retrograde signaling response that helps to maintain mitochondrial protein homeostasis. Mitochondrial ...
The chemoactivation of mitochondrial caseinolytic protease P (ClpP) has shown to have anticancer effects on many tumors, but has seldom been elucidated in MM. Here we found that the CLPP expression was elevated in MM patients, and further increased in relapsed cases. After synthesizing and ...
et al. Loss of mitochondrial protease CLPP activates type I IFN responses through the mitochondrial DNA–cGAS–STING signaling axis. J. Immunol. 206, 1890–1900 (2021). Article CAS PubMed Google Scholar Download references Acknowledgements The authors acknowledge the support of the European ...
mitochondria and degraded by the mitochondrial protease Lon. However, when mitochondria are damaged, the import efficiency of mitochondria is decreased, leading to a nuclear accumulation of ATFS-1 andhsp-6upregulation8. Once activated, UPRmtnot only upregulates mitochondrial protective proteins such as ...
The biological function of most mitochondrial proteases has not been well characterized. Moreover, most of the available information on the normal function of these proteases has been derived from studies in model organisms. Recently, the mitochondrial proteases caseinolytic protease P (CLPP) and ...
Mitochondrial ClpP is a serine protease located in the mitochondrial matrix. This protease participates in mitochondrial protein quality control by degrading misfolded or damaged proteins, thus maintaining normal metabolic function. Mitochondrial ClpP is
Mitochondrial protease ClpP is a target for the anticancer compounds ONC201 and related analogues ACS Chem. Biol., 14 (2019), pp. 1020-1029 View articleCrossrefView in ScopusGoogle Scholar 68 M. Rep, J.M. van Dijl, K. Suda, G. Schatz, L.A. Grivell, C.K. Suzuki Promotion of mit...
Summary From an shRNA screen, we identified ClpP as a member of the mitochondrial proteome whose knockdown reduced the viability of K562 leukemic cells. Expression of this mitochondrial protease that has structural similarity to the cytoplasmic proteosome is increased in leukemic cells from approximately...
上海玉博生物科技有限公司主要致力于“ATP-Dependent Clp Protease Proteolytic Subunit, Mitochondrial (CLPP) Antibody abx456224”的生产销售。多年的“ATP-Dependent Clp Protease Proteolytic Subunit, Mitochondrial (CLPP) Antibody abx456224”生产与销售的经验,与
expression of either αSyn WT or A53T had no effect on the mitochondrial matrix protease LonP or the ClpP ATP-binding subunit ClpX-like (ClpX, an essential component of ClpXP protease complex [44]) in the above cell cultures (Fig.1a, b). The level of ClpP mRNA was not altered in α...