The mitochondrial networking factor (MNF) is lower in human PAH PASMCs and mdivi-1 (25 μmol/L), an inhibitor of DRP-1, reverses the fragmented phenotype and increases the MNF, demonstrating that increased DRP-1 activity is the major determinant of the fragmented mitochondrial morphology in ...
et al. Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1alpha. Kidney Int. 84, 545–554 (2013). Article CAS PubMed Google Scholar Nayak, B. K. et al. HIF-1 mediates renal fibrosis in OVE26 type 1 diabetic mice. Diabetes ...
Cells were grown in organoid growth medium supplemented with 1× B27, 0.1 mM N-acetyl-l-cysteine (Sigma-Aldrich), mouse recombinant epidermal growth factor (R&D Systems, Minneapolis, MN), 2.0% Noggin/R-Spondin-conditioned media and 10 μM Y27632 (Tocris Biosciences, Bristol, UK). For H&E...
Downregulation of electron transport chain genes in visceral adipose tissue in type 2 diabetes independent of obesity and possibly involving tumor necrosis factor-alpha. Diabetes. 2006;55:1792–9. Article CAS PubMed Google Scholar Ost A, Svensson K, Ruishalme I, Brannmark C, Franck N, Krook ...
from human glioma cells through the cell membrane and bound to CD38 outside the cell membrane after starvation. Under the catalysis of CD38, NAD+ was converted into the messenger factor cADPR and re-entered the cell. Subsequently, cADPR acted on ER ryanodine receptors (RyRs) to initiate the...
Thus, mitochondrial shape and physical networking controls stem cell regenerative functions by regulating metabolism and proteostasis. As mitochondrial fission occurs less frequently in the satellite cells in older humans, our findings have implications for regeneration therapies in sarcopenia. Graphical ...
The triggering factor that activates the mitochondrial unfolded protein response is still questionable; it is important to preserve a balance between the expression levels of multiple proteins in the mitochondria, including those of the respiratory chain complex.70 Recent studies suggest that crosstalk ...
Our investigation unveiled that the mRNA expression levels of the transcription factor Nfe2l2, a crucial regulator of endogenous antioxidant defense mechanisms, along with the antioxidant enzymes Gpx1, Cat, and Sod2, showed no significant differences following Sirt4 knockdown in chondrocytes compared to...
The triggering factor that activates the mitochondrial unfolded protein response is still questionable; it is important to preserve a balance between the expression levels of multiple proteins in the mitochondria, including those of the respiratory chain complex.70 Recent studies suggest that crosstalk ...
AcCoA, acetyl coenzyme A; AIF, apoptosis inducible factor; ATFS1, activating transcription factor associated with stress-1; cf-mtDNA, cell-free mitochondrial DNA; Cholest, cholesterol; Cyt c, cytochrome c; DELE1, DAP3-binding cell death enhancer 1; ER, endoplasmic reticulum; FGF21, fibroblast...