Mitochondrial fission factor (Mff) is a tail-anchored MOM protein that, similar to Fis1, induces elongation of the mitochondrial network upon depletion by RNA interference (Gandre-Babbe and van der Bliek, 2008). From:International Review of Cell and Molecular Biology,2012 ...
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Mff (mitochondrial fission factor) was recently identified as a regulator of mitochondrial division[67]. Similar to hFis1, Mff is a C-tail anchored protein of themitochondrial outer membranewhose depletion attenuates mitochondrial division. Interestingly, the two proteins exist in separate complexes...
MFF: Mitochondrial fission factor Mfn1: Mitofusin 1 Mfn2: Mitofusin 2 MIP-1α: Macrophage inflammatory protein-1 alpha MitoQ: Mitoquone MMPs: Matrix metalloproteinases MPTP: Mitochondrial permeability transition pore MSCs: Mesenchymal stem cells mtDNA: Mitochondrial DNA NIX: Nip3-like ...
Mitochondrial fission factor (Mff) has been demonstrated to play a role in the activation of mitochondrial cleavage and mitochondrial death, denoting its role in the regulation of mitochondrial quality control. Recent evidence suggested that the mRNA translation of Mff is under the negative regulation ...
‘receptor’ Mitochondrial fission factor (MFF) is required for determining the size of mitochondria entering the axon and then for maintenance of their size along the distal portions of the axon without affecting their trafficking properties, presynaptic capture, membrane potential or ability to ...
In contrast, mitochondrial fission produces a large number of small fragments, mainly mediated by dynamin-related protein 1 (Drp1), fission protein 1 (Fis1), mitochondrial fission factor (Mff) and mitochondrial dynamics protein of 49 and 51 (MiD49/51) [90, 91]. During the mitochondrial life...
Specifically, FMRP promotes local translation of mitochondrial fission factor (MFF), selectively enabling replicative fission at the mitochondrial midzone. Disrupting FMRP function dysregulates mitochondria-associated MFF translation and perturbs fission dynamics, resulting in increased peripheral fission and an...
Concerning proteins directly involved in mitochondrial morphology, the mitochondrial fission factor (MFF) was among the significantly changed proteins (Supplemental Fig.S7). MFF is an essential factor in the mitochondrial recruitment of Drp1. Drp1 mediates mitochondrial fission [39]. Interestingly, the ...
(i)mitochondrial fissionfactor (MFF), (ii,iii)mitochondrial dynamicsproteins of 49 kDa (MID49) and 51 kDa (MID51), and (iv)mitochondrial fission1 protein (FIS1), whereMFFis the primary receptor that docks DRP1 on the OMM [25,26]. Focal accumulation of DRP1 receptor proteins at ...