Mitochondrial dysfunction, resulting from structural and functional changes, is linked to age-related degenerative diseases. This review focuses on mitochondrial dysfunction, its implications in aging and age-related disorders, and potential anti-aging strategies through targeting mitochondrial...
A better understanding of mitochondrial dysfunction during ageing and age-related metabolic diseases will provide fundamental knowledge to develop therapies to combat late-life morbidities. Human longitudinal studies will be essential to understand individuals’ risk of diseases much earlier in life, and wi...
Population variability, as indexed by the F-value, was significantly greater in the ASD group as compared with the control group for all biochemical markers of mitochondrial dysfunction except ubiquinone, with the difference particularly marked for pyruvate. This is consistent with the notion that a ...
This chapter reviews the evidence that a decline in mitochondrial function contributes to certain neurodegenerative disorders, to the aging process, and to... AHV Schapira - 《Mitochondrial Disorders in Neurology》 被引量: 354发表: 1994年 Mitochondrial dysfunction in neurodegenerative disorders. There ...
which has also been shown to harbor more severe neurodegeneration40. The mechanism underlying this association is currently unknown but may be related to more widespread and severe neuronal dysfunction and loss in CI-PD, induced by the CI deficiency. This is corroborated by the bulk RNA-seq data...
Mitochondria are essential organelles involved in cellular energy production. Changes in mitochondrial function can lead to dysfunction and cell death in aging and age-related disorders. Recent research suggests that mitochondrial dysfunction is closely
One of the medical disorders that has been consistently associated with ASD is mitochondrial dysfunction. Individuals with mitochondrial disorders without concomitant ASD manifest dysfunction in multiple high-energy organ systems, such as the central nervous, muscular, and gastrointestinal (GI) systems. ...
Characterization of the mitochondrial function and genetics in the pathogenesis of collagen VI related disorders (958.1) Background: Alteration in the collagen VI protein causes Bethlem Myopathy and Ullrich Congenital Muscular Dystrophy. Mitochondrial dysfunction, ultrastructural defects, increased apoptosis and...
electron transport chain; meta-analysis; mitochondrial dysfunction; regression; systematic review Introduction Autistic disorder, Asperger syndrome and pervasive developmental disorder-not otherwise specified com- prise a heterogeneous group of neurodevelopmental disorders known as autism spectrum disorders (ASDs)...
Although fibrosis is a common pathological feature of most end-stage organ diseases, its pathogenesis remains unclear. There is growing evidence that mitochondrial dysfunction contributes to the development and progression of fibrosis. The heart, liver,