Base editing in nuclear DNA and mitochondrial DNA (mtDNA) is broadly useful for biomedical research, medicine, and biotechnology. Here, we present a base editing platform, termed zinc finger deaminases (ZFDs), composed of custom-designed zinc-finger DNA-binding proteins, the split interbacterial ...
线粒体疾病是由核DNA(nuclear DNA,nDNA)或线粒体DNA(mitochondrial DNA,mtDNA)突变引起的一组复杂的先天性代谢缺陷,线粒体病在儿童中的总体发病率达1/2000左右,成年人患病率约1/4300,是最常见的遗传代谢病之一。 线粒病致死率及致残率很高。致病性线粒体DNA变异的人群携带率约为1/200,其中m.3243A>G突变的...
Conplastic mice that share the same nuclear genome but have different mitochondrial DNA were analysed throughout their life — the mitochondrial genome affects many aspects of physiology and results in differences in median lifespan; the authors propose
Nuclear DNA (nDNA) is composed of several linear chromosomes, which encodes almost all the proteins required by the cell. Mitochondrial DNA is short compared to the nuclear DNA. The main difference between mitochondrial DNA and nuclear DNA is that mitochondrial DNA is encoded for the genetic ...
细胞核DNA 1. Application ofNuclear DNAin Populus Genetics; 细胞核DNA在研究杨属植物遗传中的应用 2. The relationship between nuclear DNA and cytoplasmic DNA was discussed in this paper. 从线粒体DNA、叶绿体DNA和线粒体质粒DNA方面较详细地阐述了高等植物细胞质雄性不育的分子机理及最新进展;探讨了细胞核...
1.Application of Nuclear DNA in Populus Genetics;细胞核DNA在研究杨属植物遗传中的应用 2.The relationship between nuclear DNA and cytoplasmic DNA was discussed in this paper.从线粒体DNA、叶绿体DNA和线粒体质粒DNA方面较详细地阐述了高等植物细胞质雄性不育的分子机理及最新进展;探讨了细胞核DNA和细胞质DNA...
Hereditary diseases mainly come from mutations in the nuclear genome but they may come from mutations in the mitochondrial DNA (mtDNA) of the ovum. Hereditary mitochondrial diseases may be transmitted by either parent and, actually, the diagnosis may not be an easy task [1]. Surely, ...
Extensive damage in H2O2-induced DNA in mitochondria; Repair of mitochondrial DNA and nuclear DNA; Correlation of persistent mtDNA damage with the loss of mitochondrial function.YakesF.MichaelVanHoutenBennettEBSCO_AspProceedings of the National Academy of Sciences of the United States of America...
phylogeographysexual selectionWe analyze variation in phenotypes and mitochondrial DNA (mtDNA) haplotypes over the breeding ranges of hermit and Townsend's ... S Rohwer,E Bermingham,C Wood - 《Evolution》 被引量: 1007发表: 2001年 Mitochondrial and nuclear DNA phylogeography of Thymallus spp. (...
In humans, mitochondrial DNA spans 16,569 DNA building blocks (base pairs),[16] representing a fraction of the total DNA in cells. Unlike nuclear DNA, which is inherited from both parents and in which genes are rearranged in the process of recombination, there is usually no change in mtDNA...