Mitochondrial Complex I (MCI) deficiency has been abundantly observed in Parkinson’s disease (PD); however, it remained elusive if this was a consequence of the disease defects or rather disease-causing. Recent work in Nature by Gonzalez-Rodriguez and colleagues discovered MCI dysfunction to be s...
Consolidating biallelic SDHD variants as a cause of mitochondrial complex II deficiency Article Open access 20 May 2021 High prevalence of m.1555A > G in patients with hearing loss in the Baikal Lake region of Russia as a result of founder effect Article Open access 03 July 2024 Int...
Congenital deficiency of two polypeptide subunits of the iron-protein fragment of mitochondrial complex I. (1987). Congenital deficiency of two polypeptide subunits of the iron-protein fragment of mitochondrial complex I. J. Clin. Invest. 79, 463–467.More... RW Moreadith,MWJ Cleeter,CI Ragan...
Mitochondrial complex I impairment in leukocytes from type 2 diabetic patients Free Radic. Biol. Med., 50 (10) (2011), pp. 1215-1221, 10.1016/j.freeradbiomed.2011.01.019 View PDFView articleView in ScopusGoogle Scholar [38] B.B. Lowell, G.I. Shulman Mitochondrial dysfunction and type 2...
Knockdown of Htd2 in 3T3-L1 preadipocytes or differentiated 3T3-L1 mature adipocytes impaired mitochondrial function via suppression of complex I activity, resulting in enhanced oxidative stress and impaired insulin sensitivity, which were all attenuated by supplement of lipoic acid. Moreover, lipidomic...
Using this procedure, we were able to evaluate the individual activities of NADH dehydrogenases, succinate dehydrogenase (Complex II) and cytochrome C oxidase (Complex IV). No differences in activity for all the observed complexes could be found between Col-0 and KO plants (Figure 3A). In ...
Respiratory chain complex I deficiency caused by mitochondrial DNA mutations 喜欢 0 阅读量: 18 作者: Swalwell,H.,Kirby,D. M.,Blakely,E. L.,Mitchell,A.,Salemi,R.,Sugiana,C.,Compton,A. G.,Tucker,E. J.,B. X.,Lamont,P. J. 展开 ...
which helped the cells functional oxygen consumption and respiration. In addition, mitochondrial transfer helped ρ0 cells restore their cellular behaviour, including nonadherent proliferation, aerobic viability, and OXPHOS dependent cellular motility [83]. Moreover, ETC complex V-inhibitor-sensitive ATP ...
Accumulating evidence suggests mitochondria as key modulators of normal and premature aging, yet whether primary oxidative phosphorylation (OXPHOS) deficiency can cause progeroid disease remains unclear. Here, we show that mice with severe isolated respiratory complex III (CIII) deficiency display nuclear ...
complex cardiac phenotype involving a combination of cardiomyocyte hypertrophy, fibrosis, arrhythmia, and contractile dysfunction43. NOXs have been implicated in many of these phenotypes, and NOX expression is upregulated in numerous independent studies of HF44,45. Within the NOX family, NOX2 and 4...