Kinzler I, Haseroth E, Hauser C, Rűck A (2007) Role of mitochondria in cell death induced by Photofrin-PDT and ursodeoxycholic acid by means of SLIM. Photochem Photobiol Sci 6: 1332-1340.Role of mitochon-dria in cell death induced by Photofrin-PDT and ursodeoxy-cholic acid by means ...
使用声波降解法disintegration of MVStress并没有影响其对IL8表达的诱导能力,也没有影响内皮细胞ICAM-1 (intercellular adhesion molecule) 或 VCAM (vascular cell adhesion molecule) mRNA的表达。 有报道显示LPS刺激会改变线粒体活性。因此作者推测this defines the proinflammatory potential of MVStress。 Fig 2b:首...
Mitochondria are indispensable organelles for maintaining cell energy metabolism, and also are necessary to retain cell biological function by transmitting information as signal organelles. Hypoxia, one of the important cellular stresses, can directly regulates mitochondrial metabolites and mitochondrial reactive...
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected functions and undergo dynamic and often reversible physiological recalibrations. Given their multifunctional and malleable nature, the frequently used terms ‘mitochondrial function’ and ‘mitochondrial dysfunction’ are misleading ...
However, it was not known whether the p gene is involved in regulating the proliferation and differentation of melanocytes during development, especially the biogenesis of melanosomes and other organelles. Epidermal cell suspensions of neonatal dorsal skin derived from mice wild type for the p locus...
Theinvivofunctioning ofmitochondria isolated fromtwoto- bacco cell lines insuspension culture (Nicotiana tabacum/gossit), wildtype, andNaCI-adapted (A190), hasbeencompared inthe faceofrising external salinity. The02uptake ofbothstate 3and state 4mitochondria wasprogressively inhibited withincreasing exter...
Depending on the specific cell type, specific pathways are favoured. Excitable cells, such as neurons and cardiomyocytes, mainly rely on oxidative phosphorylation to produce ATP. As briefly discussed above, mitochondrial Ca2+ uptake plays an important role in the regulation of mitochondrial activity, ...
Photoreceptors, a nonproliferating cell type, provide a unique model for measuring the functional utilization of NADPH at the single cell level. In these cells, NADPH availability can be monitored from the reduction of the all-trans-retinal generated by light to all-trans-retinol using single ...
Prolonged photoactivation (≥15 s) of TMRM-loaded cells resulted in even stronger NAD(P)H oxidation, the rapid onset of mitochondrial permeability transition, and apoptotic cell death. These results demonstrate that NAD(P)H is the primary target for 1O2 in hepatocyte mitochondria. Thus NAD(P)H...
importance to the endothelial cell, a type of cell that usually covers over two-thirds of its energy demands by anaerobic glycolysis [32,33,118], but at a second glance, mitochondria turn out to be essential to endothelial function in many ways and are far more than just a source of ATP...