Though mitochondria possess their own genome and translation machinery, only a small number of mitochondrial proteins, including a few core constituents of the respiratory chain complexes, are encoded by mtDNA and synthesized within the organelle. Thus, the vast majority of mitochondrial proteins are nu...
Mitochondria possess their own genome, a 16,569 bp double-stranded, circular DNA molecule (mtDNA) which encodes for 13 polypeptides of the mitochondrial respiratory chain, 22 tRNAs and 2 rRNAs required for mitochondrial protein synthesis (Fig. 1). The mitochondrial genome also contains a non-...
Although most mitochondrial proteins are nuclear-encoded, mitochondria also possess their own small genome, the mitochondrial DNA (mtDNA). To express proteins encoded in the mtDNA, mitochondria employ a specialized translation machinery including tRNAs and a mito-ribosome. Human mitoribosomes synthesize ...
Though mitochondria possess their own genome and translation machinery, only a small number of mitochondrial proteins, including a few core constituents of the respiratory chain complexes, are encoded by mtDNA and synthesized within the organelle. Thus, the vast majority of mitochondrial proteins are nu...
mitochondrial DNAendosymbiotic theorymaternal inheritanceorigin of modern humansMitochondria are cytoplasmic organelles present in all eukaryotic cells which are able to respire. They possess their own genetic system and deoxyribonucleic acid (DNA) whose size is rather small but constant in animal cells (...
Mitochondria possess their own genetic material (mitochondrial DNA or mtDNA), whose gene products are involved in mitochondrial respiration and oxidative p... S Breton,HD Beaupré,DT Stewart,... - 《Trends in Genetics》 被引量: 446发表: 2007年 Rapid segregation of heteroplasmic bovine mitodiondr...
Mitochondria are roughly the size of bacteria and float in the cytoplasm of almost every cell in the human body. They possess the unique characteristic of having a double membrane which allows them to perform a number of different biochemical reactions; one of the most important is cellular respi...
Similar to the endoplasmic reticulum (ER), mitochondria possess a stress responsive system for protein degradation named mitochondrial unfolded protein response (UPRmt) (Zhao et al., 2002). UPRmt shares with its ER analog some key components, including the AAA ATPase p97 and the cofactor Npl4 (...
They are surrounded by two membranes, likely a legacy of their ancient origin from endosymbiontic single-cell organisms, and possess their own DNA [1], [2]. The vast majority of mitochondrial proteins is however encoded by nuclear DNA, and has to be targeted towards its final mitochondrial ...
The ability of mitochondria to transform the energy we obtain from food into cell phosphorylation potential has long been appreciated. However, recent decades have seen an evolution in our understanding of mitochondria, highlighting their significance as