Both are indispensable to human beings and closely related to life and death. This article discusses the similarities in various aspects between mitochondria and Yang Qi, including body temperature, aging, newborns, circadian rhythm, immunity, and meridian. It is well-known that Yang Qi is vital ...
Yet the role of mitochondria in human life and death has been overlooked for over four decades in the legal and bioethical literature, which has focused instead on processes at the whole-organism level. Challenges remain however: if brain death and bodily death are not biologically equivalent, ...
Since modern foods are unnaturally enriched in single metabolites, it is important to understand which metabolites are sensed by the human body and which are not. We previously showed that the fatty acid stearic acid (C18:0) signals via a dedicated pathway to regulate mitofusin activity and there...
Mitochondrial export into the extracellular space is emerging as a fundamental cellular process implicated in diverse physiological activities. Although a few studies have shed light on the process of discarding damaged mitochondria, how mitochondria are exported and the functions of mitochondrial release re...
Researchers have successfully transplanted the genetic material in the nucleus of a fertilized human egg into another fertilized egg, without carrying over mitochondria, the energy-producing structures of the cell. The technique could be used to prevent babies from inheriting diseases caused by mutations...
Coller HA, Khrapko K, Bodyak ND, Nekhaeva E, Herrero-Jimenez P, Thilly WG (2001) High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection. Nat Genet 28:147–150 Article CAS PubMed Google Scholar Cosentino C, Grieco D, Costanzo V (2011...
Many chronic disorders are caused by the generation of mitochondrial ROS, reactive nitrogen species (RNS) and sulfur dioxide species (SOS) in the human body119. Thus, to understand and detect characteristics (e.g., concentration, lifetime, species, etc.) of ROS, RNS and SOS, the development...
Mitochondria play a central role in various critical cellular processes, including energy synthesis, energy supply and apoptosis. Panax notoginseng, a commonly used traditional Chinese medicine, has various pharmacological effects on the human body. Ginsenosides are representative bioactive components of P....
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012. Induced by iron overload and ROS accumulation, ferroptosis is modulated by various cellular metab
For many years, the relative lack of cancer cell dependency on other cells led many researchers to mistakenly ignore the fact that cancer cells do not exist in a vacuum. As disseminated cells move throughout the body, the success or failure in establishing metastases is determined as much by ...