which is the name given to the body's energy production process. Through a process called respiration, mitochondria produce energy for cells by oxidizing substances that are synthesized in the cytosol of the cell, a process known as the citric acid cycle. The fuel that is then produced is in...
Mechanisms of reciprocal control of reactions and processes involved in energy production by mitochondriamitochondriarespiration ratesfunctionCorrelations between respiration rates in the mitochondria in different states are studied using various oxidation substrates. Specific features and integration between ...
These processes broaden the traditional role in energy production undertaken by mitochondria and provide new directions for potential therapeutic leads. 展开 关键词: Mitochondria Fusion Fission ROS Signaling DOI: 10.1007/s00109-010-0662-x 被引量: 33 ...
We show that glucose oxidation is attuned from energy production under MR to synthesis of particular amino acids, such as arginine and leucine. Mechanistically, we demonstrate that lipoate biosynthesis, a mitochondrial radical SAM-dependent process, is constrained by MR, which conveys the SAM ...
energy production2. Distinct from these processes, mitochondria also participate in the regulation of cell apoptosis3, reactive oxygen species (ROS) generation4and the ER-stress response5. Similar to their roles in nucleated cells, mitochondria in platelets also regulate metabolism, ATP production, ...
Survival is a dynamic, energy-requiring process and must be distinguished from so-called "aging" of organelles at ice temperatures. As a manifestation of partial autonomy, survival may prove useful in assessing aspects of mitochondrial function and the mitochondrial-cellular interrelationship. 展开 ...
First, mitochondria regulate energy production and are known as the “power house” of the cell, essential for all life. Second, during programmed cell death (i.e., apoptosis), numerous cell death-related signal transduction pathways are activated by mitochondria. Mitochondria have the ability to...
The skin is a high turnover organ, and its constant renewal depends on the rapid proliferation of its progenitor cells. The energy requirement for these metabolically active cells is met by mitochondrial respiration, an ATP generating process driven by a series of protein complexes collectively known...
S. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab. 17, 491–506 (2013). Article CAS PubMed PubMed Central Google Scholar Picard, M. & Turnbull, D. M. Linking the metabolic state and mitochondrial DNA in chronic disease, health, and aging...
a very energy-demanding process. ATP is necessary to power ion pumps, support ion gradients, and maintain vesicle recycling and mitochondrial movement. Remarkably, the number of mitochondria in synaptic terminals and axons exceeds the predicted energy needs [20], which implies that they have addition...