Therefore, Nuc1p and EndoG appear to have a similar downstream role, exerting their pro-death action upon exit from mitochondria and translocation to the nucleus. In respiring cells, NUC1 deletion protects from apoptosis induced by chronological aging, whereas in glucose medium NUC1 deletion has ...
In addition to the cytosol, miRNAs have been identified in other cellular compartments and organelles, including the mitochondria. While a few mitochondria-associated miRNAs (mitomiRs) are predicted to be derived from the mitochondrial genome, the majority appear to be transcribed from nuclear DNA ...
PD brain mitochondria have reduced mitochondrial respiratory protein levels in complexes I-V, implying a generalized defect in respirasome assembly. These deficiencies do not appear to arise from altered point mutational burden in mtDNA or reduction of nuclear signaling for mitochondrial biogenesis, implyin...
cerebellum, hippocampus, and prefrontal cortex (PFC) when compared to wild-type (WT) mice [107]. Primary hippocampal neurons obtained fromFmr1-knockin (KI) premutation mice showed a decreased population of mitochondria and reduced mitochondrial trafficking [108]. Another study performed in primary neu...
Leiomyoma is a rare benign, smooth muscle–derived tumor that can arise from all parts of the uveal tract.1,2 This tumor can cause diagnostic difficulties, because it may appear clinically as an amelanotic melanoma. Fewer than 30 leiomyomas of the ciliary body have been reported, but often ...
Since the glycolytic capacity of neurons is limited, they are highly dependent on aerobic oxidative phosphorylation through mitochondria for the production of energy [4]. Mitochondria are very efficient organelles in utilizing oxygen (O2) and substrates, mostly derived from glucose, to generate cellular...
(PRRs), which are able to detect PAMPs and DAMPs. In particular, TLRs and cytosolic sensors of the RIG-I-like receptor family (RLRs) can also sense the cell’s double-stranded DNA and the DNA derived from viral infection, respectively, when present in the cytosol, or single-stranded ...
Final steps of heme synthesis occur in mitochondria, therefore mitochondria appear to be a key player in the action of artemisinins, either in the heme-mediated action mode or the heme-antagonized, mitochondrial membrane-depolarization mode. We asked then what will happen if we target artemisinins...
systems with proteins of a different ancestry, and most of the increase of complexity of mitochondrial protein complexes of bacterial ancestry appear to have occurred early in eukaryotic evolution, before the eukaryotic radiation and concomitantly to the translocation of mitochondrial genes to the nucleus...
Under pathological conditions, defects in the endolysosomal system of neurons appear to affect the production, secretion, and content of exosomes, thereby affecting the progression of neurodegenerative diseases. The autophagic lysosomal pathway is a way for cells to degrade damaged organelles and long-...