结论七氟醚后处理可通过开放心肌mito-K ATP通道,进而下调Drp1表达,减轻大鼠心肌缺血再灌注损伤。 关键词: 麻醉药,吸入;心肌再灌注损伤;线粒体蛋白质类;后处理;KATP通道 ABSTRACT ObjectiveTo investigate the relationship between dynamin-related protein 1(Drp1) and mitohondrial K ATP(mito-K ATP) channel du...
Using both loss- and gain-of-function assays, we also demonstrate that the Drp1- and DDP/TIMM8a-dependent mitochondrial fragmentation observed during PCD is an important step in mitoptosis, which in turn is involved in caspase-independent cell death. Thus, following Bax/Bak-mediated mitochondrial...
目的探讨七氟醚后处理减轻大鼠心肌缺血再灌注损伤时线粒体动力相关蛋白(Drp1)与线粒体ATP敏感性钾通道(mito-KATP通道)的关系。方法清洁级健康成年雄性SD大鼠40只,体重220～280 g,采用随机数字表法分为5组(n=8):假手术组(S组)、心肌缺血再灌注组(I/R组)、七氟醚后处理组(S-Post组)、七氟醚后处理+5-...
CaM kinase induced Drp1 p regulates mito morphologyHan, XiaojianLu, YunfeiLi, ShunaiKaitsuka, TakuSato, YasufumiTomizawa, KazuhitoNairn, Angus CTakei, KohjiMatsui, HidekiMatsushita, Masayuki
目的 探讨七氟醚后处理减轻大鼠心肌缺血再灌注损伤时线粒体动力相关蛋白(Drp1)与线粒体ATP敏感性钾通道(mito-KATP通道)的关系。方法 清洁级健康成年雄性SD大鼠40只,体重220～280 g,采用随机数字表法分为5组(n=8):假手术组(S组)、心肌缺血再灌注组(I/R组)、七氟醚后处理组(S-Post组)、七氟醚后...
doi:10.21203/rs.3.rs-1096882/v1Sanjib GuhaAnson ChengTrae CarrollGail VW Johnson
(2005) Bax/Bak-dependent release of DDP/TIMM8a promotes Drp1-mediated mitochondrial fission and mitoptosis during programmed cell death. Curr. Biol. 15: 2112-8.Arnoult D, Rismanchi N, Grodet A, Roberts RG, Seeburg DP, Estaquier J, Sheng M, Blackstone C (2005) Bax/Bak-dependent release...