Mitochondrial autophagy, or mitophagy, has emerged as a key quality control (QC) mechanism to sustain the integrity of eukaryotic mitochondrial networks. We recently reported the development of mito-QC, a novel reporter mouse model that enables the high-resolution study of mammalian mitophagy with ...
using the reporter mRFP-GFP-LC3 it is possible to label different stages in autophagy by monitoring the evolution of the fluorescence emission profile resulting from the acidification of the autophagosome23,24. However, despite their widespread use, biosensors based on large protein constructs suffer ...