Riazy M, Kalloger SE, Sheffield BS, Peixoto RD, Li-Chang HH, Scudamore CH, et al. Mismatch repair status may predict response to adjuvant chemotherapy in resectable pancreatic ductal adenocarcinoma. Mod Pathol. 2015;28:1383-9.Riazy M, Kalloger SE, Sheffield BS, et al. Mismatch repair ...
Case report: mismatch repair proficiency and microsatellite stability in gastric cancer may not predict programmed death-1 blockade resistance Anti-programmed death-1 therapy has poor efficacy in mismatch repair-proficient (pMMR) colorectal cancers; however, its efficacy in pMMR gastric cancers re... ...
Purpose: To evaluate mismatch repair (MMR) status in a series of high-grade endometrial carcinomas and correlate it with several clinicopathological characteristics and with survival. Methods: One hundred and one patients with high-grade endometrial carcinoma, both of endometrioid and of non-endometrioi...
However, when we analysed the MMR status by western blot (Figure 2), losses of MLH1 and PMS2 expression were found in D341Med cells, while all the MMR proteins investigated were normally expressed in DAOY. MB tumours are MMR proficient, some MB cells are MMR deficient, and the majority ...
Multiple primary colorectal carcinomas (CRCs) synchronous, when detected approximately at the same time, or metachronous, when a significant amount of time has elapsed between diagnoses can show both mismatch repair (MMR) status concordance and discordance between primary tumors. The aim was to evalua...
Cancer risk and overall survival in mismatch repair proficient hereditary non-polyposis colorectal cancer, Lynch syndrome and sporadic colorectal cancer[J] . Pilar Garre,Lorena Martín,Inmaculada Bando,Alicia Tosar,Patricia Llovet,Julián Sanz,Atocha Romero,Miguel Hoya,Eduardo Díaz-Rubio,Trinidad Caldés...
Mismatch repair immunohistochemistry confirmed the mismatch repair-deficiency status of all cases with alterations in the tested proteins. As expected, mismatch repair-deficient sarcomas showed a significantly elevated tumor mutation burden relative to mismatch repair-proficient sarcomas (median 16 versus 4.6...
Conclusion Colon tumors show differential expression of miRNAs depending on mismatch repair status. miRNA expression in colon tumors has an epigenetic component and altered expression that may reflect a reversion to regulatory programs characteristic of undifferentiated proliferative developmental states.Peer...
MMR status was extracted from patient records or determined by testing formalin-fixed paraffin-embedded tumor tissue for the expression of four MMR proteins (MLH1, MSH2, MSH6, PMS2). From this, patient tumors were characterized as either deficient (dMMR) or proficient (pMMR) mismatch repair. ...
Mismatch Repair Status and the Response of Human Cells to Cisplatin[J] . Elisabetta Pani,Lovorka Stojic,Mahmoud El-Shemerly,Josef Jiricny,Stefano Ferrari.Cell Cycle . 2007 (14)Pani, E., Stojic, L., El-Shemerly, M., Jiricny, J. and Ferrari, S. (2007): Mismatch repair status and ...