Advances of researches on the composition and function of DNA mismatch repair system; DNA错配修复系统组成和功能的研究进展 3. Frequent Ki-ras Mutation in MSI-H Colorectal Cancer Deficient in DNA Mismatch Repair Genes; DNA错配修复基因缺陷的MSI-H大肠癌频发Ki-ras基因点突变 更多例句>> 3) Mismat...
Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes, most frequently MLH1 and MSH2. Recently, MMR-deficient crypt foci (MMR-DCF) have been identified as a novel lesion which occurs at high frequency in the intestinal mucosa from Lynch syndrome mutation carriers, ...
repair process may impact on the management of CRC, including surgery, adjuvant chemotherapy and the choice of systemic agents for the palliation of advanced disease. We also discuss how the DNA repair defect in MMR deficient CRC could be exploited in the development of novel therapeutic ...
Mismatch repair deficient colorectal cancer in the era of personalized treatment The molecular and genetic subtyping of cancer has allowed the emergence of individualized therapies. This approach could potentially deliver treatments tha... M Hewish,CJ Lord,SA Martin,... - 《Nature Reviews Clinical ...
A deficient mismatch repair system (dMMR) is present in 10–20% of patients with sporadic colorectal cancer (CRC) and is associated with a favourable prognosis in early stage disease. Data on patients with advanced disease are scarce. Our aim was to investigate the incidence and outcome of sp...
The postreplicative DNA mismatch repair (MMR) system maintains genome integrity by recognizing and repairing mismatched nucleotides that result from misincorporation during DNA synthesis. The genes coding for MMR proteins are highly conserved throughout
Mismatch repair deficient (dMMR) gastro-oesophageal adenocarcinomas (GOAs) show better outcomes than their MMR-proficient counterparts and high immunotherapy sensitivity. The hypermutator-phenotype of dMMR tumours theoretically enables high evolvability
4) DNA mismatch repair enzyme DNA错配修复酶 1. Construction of hMSH2-deficient cell strain ofDNA mismatch repair enzyme; DNA错配修复酶hMSH2缺陷细胞株的建立 5) DNA mismatch repair genes DNA错配修复基因 1. Objective:To study both the effect of proliferation inhibited of human endometrial carcinom...
We developed a decision model to examine the cost-effectiveness of dostarlimab for patients with progressive/recurrent deficient mismatch repair (dMMR) endometrial cancer whose disease has progressed with first-line chemotherapy. Design Cost-effectiveness study. Population Hypothetical cohort of 6000 women...