While triggering mitotic arrest, the chromosome mis-segregation-induced alterations of nuclear envelope mechanics provide a fitness advantage for aneuploid cells by promoting nuclear deformation resilience and enhancing pro-invasive capabilities. Collectively, this work identifies a nuclear mechanical checkpoint ...
Dividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a hallmark of cancer, a disease defined by increased ...
byCold Spring Harbor Laboratory Bovine embryos were examined for abnormal chromosome segregation during development. Credit: Maaike Catteeuw, Ghent University Single-cell embryos contain a set of maternal and paternal chromosomes, and as the embryo grows, daughter cells receive a copy of each. In a ...
Chromosome missegregation was proposed two decades ago to be responsible for neurodegeneration in AD patients. It was speculated that the aneuploidy is a result of aberrant cell cycle of neuronal progenitors during adult neurogenesis and/or of mature neurons. There is mounting evidence of increased ...
The deletion of the pka1 gene resulted in the TBZ-sensitive phenotype and chromosome mis-segregation. We isolated the mal3 gene as a multi-copy suppressor of the TBZ-sensitive phenotype in the pka1Δ strains. Overexpression of the CH domain (1–143) or the high-affinity microtubule binding ...
A model of missegregation.A model of missegregation.Discusses a study published in the February 3, 2003 issue of the 'Journal of Cell Biology,' which provides a model of chromosome missegregation caused by a dysfunction in mitotic checkpoint systems. Sensitivity of the mammalian checkpoint system...
ameḥyaf, asmeḥyef是“segregation"到 Berber 的最佳翻译。 译文示例:I don't agree with segregation of people by race. ↔ Ur qbileɣ ad yili meḥyaf gar yemdanen ɣef ljal n yiran-nsen. segregation noun 语法 The setting apart or separation of things or people, as a ...
Desegregation and EducationMotley, Constance BakerMiss.l.j
非整倍体,指的是一种细胞或生物体内染色体数目异于单倍体数目整数倍的异常状况。这一术语最早于一个多世纪前由德国动物学家Theodor Boveri在研究海胆胚胎发育过程中的细胞分裂时首次发现并提出。自那时起,非整倍体与肿瘤之间的密切联系便吸引了众多科学家的广泛关注。最新研究揭示,非整倍体现象在多种实体肿瘤中广泛...
missegregation相关词 英汉例句 Conclusion There is a significant increase with age in the number of micronuclei and missegregation. 結論在不同年齡正常人外周血淋巴細胞中,微核數隨年齡的增加而增加。 Detection the Relation Between Chromosome 21 Missegregation and Age in Cytokinesis-blocked Female Lymphocytes...