Besides, studies showed that AMSC-EXOs can rescue the polycystic phenotype and metabolic dysfunction in PCOS ovaries by transferring miR-21-5p to the livers of rats with PCOS, finally improve reproduction. However, there is no research clarified the association between miRNA-21-3p and GCs ...
但是,近年来发现miRNA*可以作为一条功能链发挥重要作用.其中研究较多的是miR-21-3p和miR-34a-3p,而miR-21-3p和miR-34a-3p表达与胶质瘤侵袭表型的相关性还没有研究进行探索.目的:分析探讨miR-21-3p和miR-34a-3p的表达水平与胶质瘤侵袭表型的相关性.方法:利用qRT-PCR检测miR-21-3p和miR-34a-3p在胶质瘤细胞(...
Exosomal miRNA‐21‐5p and miRNA‐21‐3p as key biomarkers of myocardial infarctiondoi:10.1002/hsr2.2228Sahebi, RezaGandomi, Fatemehshojaei, MitraFarrokhi, EffatHealth Science Reports
结果在小鼠肝细胞系,转染miRNA-21-3p的模拟物可以显著增加miRNA-21-3p的表达,转染miRNA-21-3p抑制剂可以显著降低miRNA-21-3p的表达(P0.01).干预miRNA-21-3p不影响细胞的体积.增加miRNA-21-3p的表达显著促进细胞增殖(P0.01),而抑制miRNA-21-3p的表达可以显著降低细胞增殖(P0.01).干预miRNA-21-3p,检测细胞周期...
The serum levels of miRNAs, i.e. miRNA-181b-5p, miRNA-223-3p, miRNA-21-5p, let 7i-5p, miRNA-29a-3p and miRNA-210-3p were significantly increased in the LoSc patients compared to the HVs. The level of let-7i increase in the female LoSc patients correlated negatively with BSA (r ...
miRNA大鼠差异表达目的探索let-7d-3p和miRNA-21-5p在二氧化硅(SiO2)诱导的大鼠纤维化肺组织中的差异表达及其意义.方法SPF级Wistar雄性大鼠随机分为对照组和模型组,每组30只,采用一次性气管内灌注1 ml SiO2悬浊液建立大鼠矽肺模型,对照组大鼠相同方法灌注1ml灭菌生理盐水.分别于染尘后1,7,14,21,28 d采集各组大鼠...