通过检测外泌体中的miRNA-196a生物标志物，可在25分钟内实现胰腺导管腺癌（PDAC）的精准诊断，灵敏度高达1.82×10－19 M，临床诊断准确率超过现有标准方法，为胰腺癌早期筛查带来新的突破。（图1）图1. SGGT传感器检测外泌体miRNA-196a的过程示意图 【文章要点】在这项工作中，作者采用BSA和polyA8的协同防污策略...
术后随访5年，根据血清miRNA-196a、miRNA-92a水平均值将宫颈癌患者分为高表达和低表达。比较高表达和低表达宫颈癌患者复发率。多因素Cox回归分析宫颈癌根治术后复发的影响因素。受试者操作特征(ROC)曲线分析血清miRNA_196a、miRNA_92a水平对宫颈癌根治术后复发的预测价值。结果宫颈癌组血清miRNA-196a、miRNA-92a...
摘要 目的探讨血清miRNA-196a联合糖类抗原19-9(CA19-9)及CA125诊断宫颈癌的临床价值。方法选取180例宫颈癌患者(宫颈癌组)、50例宫颈良性肿瘤患者(良性组)及50例健康体检者(对照组)为研究对象,比较不...展开更多 Objective To investigate the clinical value of serum miRNA-196a combined with carbohydrate ...
Furthermore, miRNA-196a is specifically captured through complementary base pairing to achieve highly sensitive and specific detection. (AuNPs/NSF) 5.5 /SPCE electrode can detect miRNA-196a in a concentration range of 1.0×10 13 to 1.0×10 6 M, and the calculated detection limit is 4.63×10 ...
Interestingly, miR196a expression is low in HPV16-positive cervical cancer cell lines but high in HPV16-negative cervical cancer cell lines. Furthermore, we found that only HPV16 early gene E5 specifically down-regulated miRNA196a in the cervical cancer cell lines. In addition, HoxB8, a known...
专利摘要:本发明公开了防治糖酯代谢疾病的miRNA、药物组合物及其应用,所述miRNA包括no‑miRNA‑18、no‑miRNA‑6中的至少一种,所述miRNA具有降脂、保肝、抗氧化应激和抗炎的作用;所述miRNA可以单独使用,也可以与miRNA‑592、miRNA‑1247‑3P、miRNA‑3072等10种miRNA进行组合,用于防治糖酯代谢疾病,降脂保...