miR663ais an inflammation-related miRNA that is frequently deregulated in human cancers. Although the expression level ofmiR663awas significantly upregulated in prostate and nasopharynx cancers, it was markedly downregulated in brain and pancreatic cancers10,11,12,13,14. It was reported thatmiR663ai...
miR-663a inhibits hepatocellular carcinoma cell proliferation and invasion by targeting HMGA2 Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2016) -2Comments pubmed: 27261623 doi: 10.1016/j.biopha.2016.04.034 issn: 1950-6007 issn: 0753-3322 ...
同时,提示我们肝纤维化可能与TERT基因突变有关,且HQT有利于基因修复.结论:TGF-β1诱导HSC活化后miR-663a低表达,lnc-C18orf26-1高表达,lnc-C18orf26-1作为miR-663a的ceRNA而调控TGF-β1和TGF-βRI的表达而激活HSC.HQT能抑制 lnc-C18orf26-1 而促进 miR-663a 表达,并调控 TGF-β1/TGF-βRI/p-Smad2...
Thus, these data demonstrate that AICD interacts with the chromatin regions of mir-3648, mir-3687, let-7a-1, mir-663, mir-3910, mir-193a and mir-595. AICD modulates the expression of miRNAs in hNSCs in a dual regulatory manner. AICD has been previously shown to contribute to the ...
结果:在强迫游泳实验中,母爱剥夺组大鼠的被动漂浮时间显著长于对照组大鼠,糖水偏爱率显著低于对照组(P0.05);与对照组比较,母爱剥夺组大鼠海马内miR-16的表达水平显著增加(P0.05),miR-16表达水平与抑郁样行为水平显著相关(P0.05)。结论:母爱剥夺能使大鼠成年后表现出抑郁样行为,海马内miR-16表达水平升...
Eukaryotic translation elongation factor 1A2 (eEF1A2) is a known proto-oncogene. We proposed that stimulation of the eEF1A2 expression in cancer tissues is caused by the loss of miRNA-mediated control. Impact of miRNAs on eEF1A2 at the mRNA and protein l