Interestingly, the profile of the upregulated miRNAs in OS compared with those in normal tissue showed that miR-224 also acted as a potential oncogene in OS (Supplementary Table 1). Next, we validated the high expression level of miR-224 in OS cell lines by qRT-PCR (Figures 3b and c)....
Compared with cells transfected with miR-23a/b mimics plus control plasmid, the cells transfected with miR-23a/b mimics plus PDCD4-overexpression plasmid exhibited a significantly higher PDCD4 protein level (Figures 4c and d), suggesting that the overexpression of miR-23a/b-resistant PDCD4 was ...
Once a key has been classified, the memory usage and key counter for the corresponding group will be incremented in a local LUA table. This aggregated metrics table will then be returned alongside the nextSCANcursor position to redis_exporter when all keys in a batch have been processed, and...
The correlations between HCG18 expression levels and clinicopathological features in human EOC specimens were analysed (Table 1). We found that HCG18 expression level in EOC tissues was significantly higher in high tumour stage (III–IV) and tumour grade (G3). Moreover, HCG18 was significantly...
(C) The relative expression level of Dtprp in vivo. (D) The relative expression levels of mmu-miR-21a in vivo. (E) Immunofluorescence analysis of Vimentin and Cytokeratin in primary endometrial stromal cells. (F) The relative expression level of Dtprp in vitro. (G) The relative expression...
a The LINC00673 expression level in MDA-MB-231, MDA-MB-453, and Hs-578 T breast cancer cells transfected with si-LINC00673 or Lv-LINC00673. b CCK-8 assays were performed to determine the cell viability in MDA-MB-231 and MDA-MB-453 cells after the knockdown of LINC00673. c The ...
Furthermore, both gain-of-function and loss-of-function analyses disclosed the suppressive effect of miR-301a on the expression of p21 mRNA and protein (Fig. 3C), and the suppressive effect on the Smad4 protein level but not mRNA level (Fig. 3D). Moreover, consistent with the miR-301a...
Cancer cell lines did not express miR-205 (or had very low expression, as in the case for H358 cells) in comparison with immortalised HBEC cells (Figure 1B and Supplementary Table 2), suggesting a tumour suppressor role for miR-205 in lung cancer. miR-205 regulates cell proliferation, ...
The level of significance was set at *P < 0.05. Results miR-29a is up-regulated in breast cancer due to bFGF miR-29a was reported up-regulated in MCF-7 spheroid cells, and CD44+/CD24− MCF-7 cell compared with MCF-7 cells by our laboratory previously6. Accordingly, we used ...
5a. To our interest, among the eight significantly downregulated miRNAs (Additional file 1: Table S4), miR-133a-3p was the most downregulated miRNA (fold change > 10) in HCT116 cells overexpressing CXCR4 and stimulated by CXC12 compared with vector control cells. GO functional analysis ...