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Interestingly, miR-16 has been reported to regulate other IBS-relevant genes of the serotonergic system, in particular the SERT geneSLC6A4, regulating serotonin bioavailability in the nervous system but also gut epithelium29. Also relevant due to the high comorbidity of IBS with psychiatric phenotype...
In conclusion, this is the first report documenting that genistein exerts its anti-tumour effect via downregulation of miR-1260b that targets sFRP1 and Smad4 in prostate cancer cells. Knockdown of miR-1260b by a specific inhibitor enhanced expression of tumour suppressor genes sFRP1 and Smad4 ...
Programmed cell death 4 (PDCD4) is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer (CRC). During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism for decreased PDCD4 expression is not fully...
The putative miR-377-3p- and miR-4269-binding sites in 3′-UTR of TEAD1, as well as the miR-1343-3p- and miR-4269-binding sites in TEAD4 3′-UTR were separately sub-cloned into pMIR-REPORT vector (Ambion, Austin, TX, USA). The sense and anti-sense of the oligonucleotides were ...
Here, we report for the first time that low choline availability reduces the transcription factor SOX4 during neurogenesis. SOX4 has critical developmental functions such as skeletal and heart development; a lack of SOX4 is lethal in utero [56,57]. Additionally, the postnatal deletion of SOX4 ...
These results are consistent with the previous report suggesting that HCV infection inhibits HNF4A expression by reducing its mRNA levels [48]. To test the consistency of this observation, results were verified using an HCV infection model of primary human hepatocytes (PHHs). It was found that ...