"MiR-371 is probably expressed in more than 90% of germ cell tumor patients. Notably, it is also expressed in seminoma, but unfortunately not in teratoma," said lead researcher Klaus-Peter Dieckmann, MD, from the Department of Urology at Albertinen-Krankenhaus Hamburg in Germany, who presente...
MiR371-373 cluster acts by modulating the function of these factors and limiting the excessive cell cycle propagation upon oncogenic stimuli to protect cells from replicative stress, but also activate CDK inhibitors and transcriptional repressors of the retinoblastoma family to cause cell cycle arrest....
Germ cell tumours (GCTs) overexpress miRNAs of the miR-371-3 cluster. Thus, serum levels of these miRNAs may correlate with tumour load. METHODS: miRNAs of the miR-371-3 cluster were quantified in cubital vein blood samples of 20 GCT patients with clinical stage 1, and of 4 patients ...
Correction to:British Journal of Cancerhttps://doi.org/10.1038/s41416-023-02453-1, published online 03 October 2023. In this article, the original title ‘Targeting oncogenic microRNAs from the miR-371 ~ 373 and miR-302/267 clusters in malignant germ cell tumours causes growth inhibition ...
hsa-miR-371b-5p agomir | MedChemExpress (MCE)面议 品牌:MedChemExpress (MCE) 厂商性质:生产商 产地类别:进口 产地:美国 货期:现货 服务地域:全国 规格:2 近期咨询:0 MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。hsa-miR-371b-5p agomirCAS No. : MCE 国际站:hsa...
产品活性:hsa-miR-371b-5p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链,全链进行甲氧基修饰,在5'端和3'端分别有2个和4个硫代骨架修饰,并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA,阻止miRNA与其靶基因的互补配对,从而抑制miRNA的功能。相比于miRNA inhibitor,miRNA ant...
Hsa-miR-371-5p inhibits human mesangial cell proliferation and promotes apoptosis in lupus nephritis by directly targeting hypoxia-inducible factor 1 alpha 喜欢 0 阅读量: 25 作者:Sun,Liqiu,Wang,Xiumei,Yao,Feifei,Xu,Jia,Fang,Wei,Cui,Rui,Dongsheng,Li,Huamin ...
There are comments on PubPeer for publication: The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer (2015)
The regulation of miR-371-373 by SMAR1 inhibits breast cancer tumorigenesis and metastasis as determined by in vivo experiments. Overall, our study highlights the binding of SMAR1 to T(C/G) repeat and its role in cancer through miR-371-373. The nuclear matrix is an intricate yet dynamic ...
In conclusion, miR-371a-3p is a sensitive and potentially novel biomarker for detecting disease relapse in TGCT patients. This promising biomarker should be investigated in further large prospective trials. Keywords: microRNAs; diagnosis; testicular cancer ...