进一步研究表明,miR-340-5p 和 miR-424-5p 可下调 PD-L1 表达,在耐药细胞中对 PD-L1 的调控起到关键作用。 miR-340-5p 和 miR-424-5p 对 ENKTL 细胞中 PD-L1 的调控探索:为了深入了解 miR-340-5p 和 miR-424-5p 对 PD-L1 表达的调控机制,研究人员在 ENKTL 细胞中转染了这两种 miRNA 的抑制剂和...
动物模型验证得到miR-340;qPCR检测结果表明miR-340可抑制HMGB1表达,荧光素酶互补实验提示miR-340可靶向结合HMGB1;功能实验结果表明HMGB1过表达可增强细胞增殖活性和I型胶原、α-SMA的表达,而miR-340 mimics不仅可抑制细胞增殖活性和HMG...
分析miR-340的表达发现,在短期生存者(short-term survivors,STS)中,miR-340的表达明显低于LTS者(p<0.05)。同时,GBM肿瘤标本中的miR-340表达明显低于正常脑组织(p<0.001)。此外,对43例来自研究者所在医院的GBM患者和来自TCGA数据库的327例患者的miR-340表达状况进行Log-Rank检验表明,miR-340表达较高的患者均具有...
在这里,通过生物信息学分析和实验验证,作者确定miR-340-5p是一个新的引起细胞衰老的miRNA。MiR-340-5p在不同的衰老模型中高度表达,miR-340-5p在增殖细胞中过表达使其衰老。在靶mRNA中,miR-340-5p显著降低了LBR mRNA的表达水平,编码...
Human MIR340 qPCR Primer Pair,即人MIR340 qPCR引物对,主要用于基于SYBR Green的qPCR、One-Step qRT-PCR或semi-quantitative PCR。本引物为预先设计、经过qPCR验证、预混的引物对。 qPCR (Quantitative PCR)即定量PCR,也称实时荧光定量PCR或实时定量PCR (Real-time quantitative PCR)、实时PCR (Real-time PCR),是...
miR-340在乳腺癌组织中的表达及意义
miR-340 has been shown to have a role in other diseases, such as autoimmune diseases, acute stroke, and alcoholic steatohepatitis. Nevertheless, the roles of miR-340 in human malignancies are still unclear, and the associated mechanisms are complex, involving a variety of signaling pathways, ...
Hsa—miR-340对膀胱癌T24细胞增殖及凋亡的影响
Ferroptosis is associated with the pathological progression of hemorrhagic injury and ischemia–reperfusion injury. According to our previous study, exosomes formed through bone marrow mesenchymal stem cells modified with miR-340-3p (MB-exos) can restore
The level of miR-340 was restored in CRC cells by the usage of the miR-340 mimic. Re-expression of RLIP76 in CRC cells was then constructed. Moreover, the target gene of miR-340 was identified through the experiment of in vivo xenograft model. The aberrant downregulation of miR-340 is...