本发明公开了miR‑302c‑3p在制备治疗椎间盘退变药物中的应用。本发明通过转染mimics在NPCs内过表达miR‑302c‑3p,同时运用特异性miRNAinhibitor下调NPCs的miR‑302c‑3p水平,对比miR‑302c‑3pGain/Loss对NPCs的影响,发现miR‑302c‑3p对退变椎间盘有再生激活的作用;因此上调miR‑302c‑3p...
miR-302c expression was markedly induced by IL-1β treatment in OA chondrocytes. miR-302c suppressed the expression of TGFBR2 via direct binding to its 3′- untranslated region. Similar to TGFBR2 overexpression, miR-302c inhibition significantly improved IL-1β-induced degenerative changes in OA...
英文名称: miRNASelect? pEP-hsa-mir-302c Expression Vector 总访问: 162 国产/进口: 进口 半年访问: 12 产地/品牌: 美国Cell Biolabs 产品类别: 细胞生物学试剂 规格: MIR-302C 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 ...
Compared to miR-302c, miR-520e cannot promote viral replication and production, although the two microRNAs target the same site of the NIK 3'UTR. Collectively, our work defines a novel signaling pathway implicated in the control of IFNβ mRNA expression during IAV infection. 展开 关键词: ...
MiR-302c inhibits tumor growth of hepatocellular carcinoma by suppressing the endothelial-mesenchymal transition of endothelial cells Kai Zhu1*, Qi Pan1*, Luo-qi Jia2*, Zhi Dai1, Ai-wu Ke1, Hai-ying Zeng3, Zhao-you Tang1, Jia Fan1 & Jian Zhou1,4 1Liver Cancer Institute, Zhong Shan...
货号:gga-miR-302c-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:gga-miR-302c-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制...
MiR-302c NF-κB-inducing kinase Type I IFN Innate immune 1. Introduction Influenza A virus (IAV) is a leading cause ofrespiratory illnessin humans. IAV is responsible for seasonal epidemics and periodic pandemics that have serious economic impact[1]. Influenza Avirus infectiontriggers intra- and...
FULL PAPER British Journal of Cancer (2013) 109, 723–730 | doi: 10.1038/bjc.2013.337 Keywords: NKG2D ligands; miR-302c; miR-520c; 1,25(OH)2D3 Downregulation of miR-302c and miR-520c by 1,25(OH)2D3 treatment enhances the susceptibility of tumour cells to natural killer cell-...
Journal of Experimental & Clinical Cancer Research (2016) 35:25 DOI 10.1186/s13046-016-0300-8 RESEARCH Open Access MiR-302a/b/c/d cooperatively sensitizes breast cancer cells to adriamycin via suppressing P-glycoprotein(P-gp) by targeting MAP/ERK kinase kinase 1 (MEKK1) Lin Zhao, Yan Wang...
在HCV阳性HCC组中,发现miR-17-5p,miR-223-3p和miR-24-3p的表达谱很明显(p <0.05)。当将所有组与对照组进行比较时,发现miR-30c-5p,miR-223-3p,miR-302c-3p和miR-17-5p在肝硬化和肝癌中显着失调。这些结果表明,miR-30c-5p,miR-223-3p,miR-302c-3p和miR-17-5p可以在很早甚至在肝硬化阶段被用作...