1）MSS/EMT亚型中MIR200CHG低表达患者的总生存期较差，MIR200CHG的表达在预测两种药物的敏感性方面具有潜在的价值。2）MIR200CHG启动子在胃AIMSS/EMT亚型中高甲基化。MIR200CHG是EMT的负调控因子。3）机制上，MIR200CHG不仅促进miR-200c和miR-141的产生，而且通过直接结合miR-200c来保护miR-200c免受降解。临床相...
机制研究:MIR200CHG基因是功能已报道miR-200c和miR-141的宿主基因(图1a)。MIR200CHG表达与miR-200c和miR-141表达存在强正相关。5-Aza处理上调MIR200CHG、miR-200c和miR-141的表达(图1b-d)。表明miR-200c和miR-141与MIR200CHG具转录起始位点, MIR200CHG的转录促进了miR-200c和miR-141的产生。功能分析显示...
whereas the majority of the genes in the regulon of MIR200CHG (72.3%) were repressed by MIR200CHG (Fig.1d). Using MIR200CHG as an example, we next sought to validate the robustness of the inferred regulon. More specifically, we investigated...
Long non-coding RNAs (lncRNA) have been identified as key regulators of tumorigenesis and development. We aim to explore the biological functions and molecular mechanisms of lncRNA MIR200CHG in breast cancer. We found that MIR200CHG is highly expressed i