近日,来自上海交通大学医学院仁济医院胃肠外科赵刚、赵恩昊、郁丰荣课题团队的研究人员发现,缺氧HIF-1α诱导的miR-301a-3p表达以及缺氧胃癌细胞分泌的外泌体miR-301a-3p可促进肿瘤上皮间质转化和胃癌进展。该研究发表于Oncogene杂志上。...
由于NRG-1的缺失与TRS患者对奥氮平的治疗应答相关,我们观察到miR143-3p作用于NRG-1的下游,因此我们假设miR143-3p可能参与TRS患者的奥氮平抵抗。1 mM或10 mM奥氮平预处理显著增加miR143- 3p水平,而siRNA介导的NRG-1 KD逆转了奥氮平...
We then indicated that the mechanism by which miR-145 promotes the TNF-α-induced apoptosis is dependent on the formation of RIP1-FADD-caspase-8 complex. The cellular inhibitor of apoptosis (cIAP1), which is the inhibitor of apoptosis protein, was found to be a target of miR-145 in MDA...
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This study focuses on the conceptual category of mirativity and its construc-tional construal in English. We propose an operationalization of mirativity with a view to investigating the phenomenon within the usage-based quantitative methodology of multifactorial analysis (Geeraerts, Grondelaers, & Bak...