1.miR‑877‑3P在如下任一项中的应用: (A1)调控IGFBP5基因; (A2)提高毛乳头细胞的细胞活性; (A3)调控次级毛囊周期; (A4)生产羊绒。 2.根据权利要求1所述的应用,其特征在于,miR‑877‑3P下调IGFBP5基因表达。 3.根据权利要求1所述的应用,其特征在于,所述毛乳头细胞是次级毛囊生长期的毛乳 ...
MCE 国际站:hsa-miR-877-3p antagomir 产品活性:hsa-miR-877-3p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链,全链进行甲氧基修饰,在5'端和3'端分别有2个和4个硫代骨架修饰,并在3'端连接有高亲和性胆固醇修饰。miRNA antagomir通过特异性结合成熟miRNA,阻止miRNA与其靶基因的互补配对,从而抑制miRNA...
miR-877-3p绝经目的·研究骨质疏松症发生及发展过程中miR-877-3p对骨髓间充质干细胞(bone mesenchymal stem cells,BMSCs)增殖能力的影响.方法·8周龄的雌性健康小鼠20只,进行双侧卵巢摘除术,建立绝经后骨质疏松模型(OVX组).另选20只雌性健康小鼠,切除卵巢附近脂肪组织,建立假手术模型(假手术组).术后2个月,对2...
结果表明CA7-4可作为竞争性内源RNA(ceRNA) ,通过捕获miRNA MIR877-3P 和 MIR5680促进内皮细胞自噬和凋亡。进一步研究表明MIR877-3P通过结合在CTNNBIP1(连环蛋白Β相互作用蛋白 1)的3ʹ UTR使CTNNBIP1的表达量下调,进而使 CTNNB1(连环蛋白B1)的表达量上调。MIR5680则通过靶向和降低DPP4(二肽基肽酶4)的表达...
Myofibroblast differentiation of lung resident mesenchymal stem cells (LR-MSC) plays an important role in idiopathic pulmonary fibrosis. By comparing the expression profiles of miRNAs before and after myofibroblast differentiation of LR-MSC, we identified miR-877-3p as a fibrosis-related miRNA. We fou...
We found that miR-877-3p sequestration inhibited the myofibroblast differentiation of LR-MSC and attenuates bleomycin-induced lung fibrosis by targeting Smad7. Smad7, as an inhibitory smad in the TGF-β1 signaling pathway, was decreased in the myofibroblast differentiation of LR-MSC and up-...
miR-877-3p inhibited the mRNA and protein expression of Bcl-2. Furthermore, H19 decreased the Bcl-2/Bax ratio at mRNA and protein levels, cytochrome c release, and activation of caspase-9 and caspase-3 in myocardial I/RI mice, which were canceled by miR-877-3p. In summary, the H19...
Uterine miR-877-3p and let-7a-5p are increased during simulated menstruation in a mouse model 来自 科研支点 喜欢 0 阅读量: 16 作者:M Watters,CA Walker,AA Murray,M Nicol,JA Maybin 摘要: Lay summary Heavy periods are common and debilitating, but we do not fully understand how they are ...
构建miR-128-3p过表达和干扰质粒、LEP干扰质粒分别转染人永生化角质形成细胞HaCaT细胞。经实时定量聚合酶链反应检测miR-128-3p及LEP的mRNA,Western blotting检测LEP蛋白表达;酶联免疫吸附实验检测培养液中肿瘤坏死因子α(tumor necrosis factor...
研究表明,miR142-3p 在宫颈癌、肾癌、急性白血病、非小细胞肺癌、结肠癌、肝细胞癌、鼻咽癌、骨肉瘤、食管癌、胰腺癌及乳腺癌等恶性肿瘤中均存在异常表达,并且 miR-142-3p 可直接靶向细胞周期蛋白CDC25C,促癌基因HMGB1、TGFβR1,及多种干细胞表面特异分子如 CD...