CASC11的相对表达水平是TNBC患者预后较差的独立危险因素;Transwell实验表明下调miR-676-3p能够逆转lncRNA CASC11沉默介导的对TNBC细胞迁移和侵袭的抑制作用,双荧光素酶报告实验表明lncRNA CASC11能够调控miR-676-3p.结论lncRNA CASC11的异常高表达与TNBC的发生,发展以及不良预后密切相关,其能够通过调控miR-676-3p诱导...
Expression levels of 3 microRNAs were robustly associated with strain lifespan, after correction for multiple statistical testing (miR-203-3p [β-coefficient=0.6447,p=4.8×1011], miR-664-3p [β-coefficient=0.5552,p=5.1×108] and miR-708-5p [β-coefficient=0.4986,p=1.6×106]). Pathway ...