首先可以看到的是miR-590-5p作用于YAP的模式图,miR-590-5p结合到YAP的3’UTR区域下调YAP的表达。研究者使用miR-590-5p模拟物及其抑制剂(B图是对此模拟物作用的验证),对Caco-2和SW620两组结肠细胞癌系进行了功能获得和功能缺失实验(gain-of-function+loss-of-function studies),该实验证明miR-590-5p模拟物的使...
miR-590-5p,氧化低密度脂蛋白,人脐静脉内皮细胞,凋亡,血凝素样氧化低密度脂蛋白受体1,动脉粥样硬化目的:研究miR-590.5p对氧化低密度脂蛋白(ox-LDL)诱导人脐静脉内皮细胞(HUVECs)凋亡过程中血凝素样氧化低密度脂蛋白受体1(LOX-1)表达的调节作用,观察miR-590.5p对HUVECs凋亡的影响。方法:HUVECs经ox-LDL(50/...
miR-590-5P在人肝癌细胞中低表达,而S100A10蛋白在肝癌细胞中高表达.S100A10 3'UTR luciferase报告系统验证表明,mi R-590-5P可以通过结合S100A10 3'UTR而抑制报告基因的表达.通过慢病毒系统在HepG2细胞中高表达miR-590-5P,可有效抑制S100A10基因的表达.在肝癌细胞HepG2中过表达mi R-590-5P,可通过调控细胞周期...
MiR-590-5p对OX-LDL诱导血管内皮细胞凋亡以及LOX-1表达的影响
www.nature.com/scientificreports OPEN MiR-590-5p Inhibits Oxidized- LDL Induced Angiogenesis by Targeting LOX-1 received: 07 October 2015 accepted: 17 February 2016 Published: 02 March 2016 Yao Dai1,2,3, Zhigao Zhang3,Yongxiang Cao3, Jawahar L. Mehta2 & Jun Li1 Oxidized low...
Coxsackievirus B infection induces the extracellular release of miR-590-5p, a proviral microRNACoxsackievirus B infection induces the extracellular release of miR-590-5p, a proviral microRNACoxsackievirusMicroRNAVesiclesApoptosisCoxsackievirus B is a significant human pathogen and is a leading cause of ...
miR-590-5p suppresses hepatocellular carcinoma chemoresistance by targeting YAP1 expression 来自 学术范 喜欢 0 阅读量: 22 作者:M Chen,L Wu,J Tu,J Ji 摘要: Resistance to chemotherapeutic treatment is a common phenomenon in cancers, especially in hepatocellular carcinoma (HCC). The Hippo signaling...
miR-590-5P在肝癌细胞中过表达,可有效抑制S100A10基因的表达,抑制Wnt通路的激活,使肿瘤细胞停滞在G1期,从而参与肝癌细胞增殖进程。%Objective:To study the effect of miR-590-5P on the proliferation of hepatocellular carcinoma cells and the mechanism involved in the occurrence and development of HCC.Method...
FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p Jinglin Zhang, Yuhang Zhou, Tingting Huang, Feng Wu, Yi Pan, Yujuan Dong, Yan Wang, Aden K. Y. Chan, Liping Liu, Johnny S. H. Kw...
背景:血管新生参与早期膝骨关节炎进展,滑膜、软骨及软骨下骨均具有血管新生病理表现,探讨川芎嗪和过表达miR-20b-5p对这些组织病理性血管新生的抑制能力及相关作用途径,有助于开发新的早期膝骨关节炎治疗药物。 目的:通过组织学观察探讨...