卵巢异位病灶中miR-556-3p显著升高(P<0.001),腹膜异位病灶中miR-556-3p的表达量则显著降低(P<0.001),而VEGF显著升高(P<0.001);异位症组在位内膜及腹膜异位病灶中miR-556-3p与VEGF蛋白的表达量呈显著负相关(r值分别为-1.026,-1.819,P值分别为0.01,0.04).结论 内膜组织中miR-556-3p表达异常可能导致VEGF蛋白...
MiR-490-3p was found to be down-regulated during osteogenic differentiation of thoracic ligamentum flavum cells, while their overexpression inhibited osteogenic differentiation. In addition, the analysis of target prediction and dual luciferase reporter assays supported that miR-490-3p directly targeted ...
miR-556-3p细胞增殖迁移侵袭目的 探讨circPTPRA对乳腺癌细胞增殖,迁移和侵袭的影响及可能机制.方法 收集41例乳腺癌患者的癌组织和对应的癌旁组织,RT?qPCR检测组织中circPTPRA和miR?556?3p表达水平.体外培养乳腺癌细胞MDA?MB?231,分别转染pcDNA?circPTPRA或anti?miR?556?3p或共转染pcDNA?circPTPRA与miR?556?3p后,...
miR-556-3p level was significantly upregulated in breast cancer patients compared to control group ( P <0.05) and inversely associated with survival rate ( P <0.05). In vitro experiments, cell activity and invasion were positively correlated with miR-556-3p level ( P <0.05). In MCF-7 ...
miR⁃556⁃3p细胞增殖迁移侵袭目的 探讨circPTPRA对乳腺癌细胞增殖,迁移和侵袭的影响及可能机制.方法 收集41例乳腺癌患者的癌组织和对应的癌旁组织,RT?qPCR检测组织中circPTPRA和miR?556?3p表达水平.体外培养乳腺癌细胞MDA?MB?231,分别转染pcDNA?circPTPRA或anti?miR?556?3p或共转染pcDNA?circPTPRA与miR?556?3p...
Conversely, miR-556-3p overexpression suppressed CRC cell proliferation and migration. Moreover, deficiency of hsa_circRNA_001676 or G3BP2 repressed the CRC cell proliferation, migration and stemness. Meanwhile, hsa_circRNA_001676 deficiency obviously reduced tumor growth and stemness in a CRC mouse...
556 – Exosomal Mir-15B-3P Promotes the Development of Gastric Cancer by Targeting Dynlt1doi:10.1016/S0016-5085(19)40543-XShuchun WeiGuoxin ZhangElsevier BVGastroenterology
Our results indicated that circSLCO1B7 significantly inhibits the metastasis of HCC via the miR-556-3p/DAB2IP axis. Thus, circSLCO1B7 is a good candidate as a therapeutic target.Linling JuQian ZhouQianyi QiYongjun SheWeihua CaiYali Cao
抑制miR-556-3p表达或使SASH1过表达显著降低Ishikawa细胞活力,迁移细胞数,侵袭细胞数,以及cyclin D1,MMP-2和MMP-9蛋白水平,显著提高p21蛋白水平(P<0.05).miR-556-3p靶向SASH1并负性调控其表达.敲减SASH1的表达逆转了miR-556-3p低表达对Ishikawa细胞活力,迁移和侵袭的抑制作用.结论:抑制miR-556-3p表达可以抑制...
目的探究垂体同源框配对同源域转录因子1(pituitary homeobox paired homeodomain transcription 1,PITX1),miR-556-3p在乳腺癌肝转移中的表达.方法以2019年6月~2021年6月在笔者医院诊治的142例乳腺癌患者为研究对象,其中64例乳腺癌肝转移患者为转移组,78例未发生肝转移患者为未转移组.采用免疫组化法检测PITX1表达....