548ag的表达水平显著升高,且与受试者血糖水平显著正相关,miR-548ag可上调二肽基肽酶4(DipeptidylPeptidase-4,DPP4)的表达,抑制肝细胞葡萄糖消耗.但miR-548ag促进DPP4表达的具体分子机制尚不明确.本研究在构建饮食诱导的肥胖小鼠模型,以及体外培养人肝细胞系L02和人肝癌细胞系HepG2的基础上,明确miR-548ag是否通过...
(2) miR-548ag promotes DPP4 expression in hepatocytes via the TLR(7/8)/NF-魏B signalling pathway, resulting in a reduction in the glucose consumption capacity of hepatocytes. (3) The administration of a miR-548ag inhibitor enhanced glucose tolerance and insulin sensitivity in db/db mice....