细胞增殖和迁移实验也表明,miR - 485 - 5p 模拟物会抑制细胞的增殖和迁移,恢复 NQO1 水平后,这种抑制作用会被逆转。这说明 miR - 485 - 5p 可以通过影响 NQO1 的表达来调节 CRC 细胞的生长和转移能力,同时也影响着细胞的能量代谢途径,miR - 485 - 5p/NQO1 轴就像一个紧密配合的 “小团队”,共同影响着 C...
miR-485-5p肝癌胃癌乳腺癌恶性肿瘤MicroRNAs(miRNAs)是一类长度约22个核苷酸的非编码RNA,在基因表达调控中,参与多种重的生理和病理过程.miRNAs能够特异结合靶基因序列,抑制基因的转录或翻译,从而抑制基因在转录或转录后水平上的表达.miRNAs作为肿瘤抑制因子或促进因子在癌症发生发展中经常失调.最近的研究发现miR-485-5p在...
Transfection of HPV‐infected cervical carcinoma cells with an adenovirus vector encoding human FLOT‐1 partially diminished the inhibitory effects of miR‐485 on cell invasion. Taken, together, these data demonstrated that miR‐485‐5p suppresses the invasion of cancer cells by targeting FLOT‐1 in...
HSP903′-UTRtoinhibitAKT1andHSP90expression.miR-485-5poverexpressiondramaticallyreducedAKT1, HSP90,andki-67proteins,increasedE-cadherinproteinlevels,andinhibitedOScellproliferationandmigration.In conclusion,HSP90knockdownblockedthephosphorylationofAKT1suppressingtheproliferationandmigration capacityofOScellsviathePI3K/...
(qPCR) was carried out using SYBR-Green PCR Master Mix (Applied Biosystems, Foster City, CA, USA) on an ABI 7500 System (Applied Biosystems). The expression of miR-485-3p and miR-485-5p was examined and normalized to the internal control (GAPDH), and relative induction was calculated ...
Alzheimer’s disease (AD) is a common dementia and a heterogeneous disease. Previous research has validated that microRNAs (miRNAs) are pivotal regulators in the initiation and development of tremendous diseases including AD. MicroRNA-485-5p (miR-485-5p)
MiR-485-5p is screened as a candidate inhibitor of MAPL. Overexpression of miR-485-5p blocked mitochondrial fission and hypertrophy induced by PE through inhibiting MAPL expression and increasing the level of Mfn2 in cultured primary cardiomyocytes. In mice model of cardiac hypertrophy induced by ...
目的 探讨微小RNA-485-5p(miR-485-5p)对鼻咽癌细胞增殖和凋亡的影响及作用机制.方法 选取2016年5月～2018年4月本院行手术治疗的36例鼻咽癌患者癌组织为研究对象,对应癌旁组织距离肿瘤边缘>3cm作为对照组.RT-qPCR检测鼻咽癌组织和对应的癌旁组织中miR-485-5p和FOS样抗原2(FOSL2) mRNA水平,Pearson相关性分析鼻咽癌...
However, post-CPAP treatment, miR-210-3p levels were significantly reduced, suggesting they were sensitive to OSA treatment, whereas miR485-5p and miR-139-5p showed no changes. Interestingly, the lncRNAs MALAT1 and BACE1-AS were also significantly increased in OSA patients, with only BACE1-AS ...
货号:chi-miR-485-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:chi-miR-485-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...