此外,CircGPR137B的恢复表达在体内抑制了肿瘤的生长和肺转移。进一步的研究表明,与miR-4739共定位于细胞质中的CircGPR137B可作为miR-4739的海绵,上调其靶向FTO,从而介导CircGPR137B的m6A去甲基化,促进其表达。从而形成了一个由GPR137B/MIR-4739/FTO轴组成的反馈回路。FTO抑制细胞生长,提示肝细胞癌患者有良好的生存。
Target gene of miR-4739 and promoter activity assay was measured by using dual-luciferase reporter assay system. In vivo, pleural fibrosis was evaluated by Masson staining and miR-4739 level was detected by In situ hybridization histochemistry. Findings We found that bleomycin induced up-regulation ...
在临床胸膜纤维化标本中,miR-4739含量较高而BMP-7含量较低.5.miR-4739靶向BMP-7,破坏Smad2/3和Smad1/5/9通路间的平衡.6.BMP-7-Smad1/5/9通路促进E-cadherin启动子的活性,抑制COL1A1启动子的活性.7.过表达miR-4739诱导小鼠胸膜纤维化.8.BMP-7能够抑制博莱霉素介导的小鼠胸膜纤维化.结论:miR-4739通过...
血miR-320c,miR-4739和miR-3162-3p表达水平.比较miR-320c,miR-4739和miR-3162-3p单独检测与联合检测对ITP的诊断价值.结果:与对照组比较,ITP组患儿PLT,PCT水平显著降低,MPV,PDW水平显著增加,差异具有统计学意义(P < 0.05).RT-PCR结果显示,与对照组比较,ITP组患儿外周血miR-320c和miR-4739表达显著增加,miR-...
Park Soo-choon was the person who belonged to the leading Jaeji-Sajok in the Miryang area. Keeping up his acquaintance with a number of people in the basis of the Neo-Confucian tradition inherited from the previous generations and a wide range of teacher-pupil relations at his time, he ...