Target gene of miR-4739 and promoter activity assay was measured by using dual-luciferase reporter assay system. In vivo, pleural fibrosis was evaluated by Masson staining and miR-4739 level was detected by In
研究者发现了一种新的在肝癌组织中显著下调的CircGPR137B,并发现CircGPR137B的下调或miR-4739的上调与肝癌患者的预后不良有关。异位表达CircGPR137B可显著抑制细胞的增殖、集落形成和侵袭,而下调CircGPR137B则具有相反的作用。 此外,CircGPR137B的恢复表达在体内抑制了肿瘤的生长和肺转移。进一步的研究表明,与miR-...