故miR-126下调表达以及miR-9上调表达在wAMD发生发展中发挥着极其重要的作用,并且miR-126通过负向调控促血管生成因子VEGF、PDGF表达,以及正向调控抑制血管生成因子TIMP-1、ES表达,进而促进脉络膜新生血管形成导致的视网膜增生、渗出,且导致眼压...
目的研究miR-207在大鼠肾脏纤维化(RF)模型中的差异表达,并对其功能进行研究.方法实验组大鼠(UUO)分离并结扎右侧输尿管,假手术组只分离右侧输尿管,不结扎.Real-time PCR定量分析大鼠肾脏纤维化模型肾脏和尿液中miR-207的表达,以及瞬时转染miR-207 mimics和inhibitors的大鼠肾小管上皮(NRK-52E)细胞中纤维化相关基因...
MiR-34a acts as a candidate tumour suppressor gene, and its expression is reduced in several cancer types. We aimed to study miR-34a expression in breast cancer and its correlation with tumour characteristics and clinical outcome, and regulatory links with other genes. We analysed miR-34a express...