A role for miR-34a has also been repeatedly reported in both type 1 and type 2 diabetes as well as in age-associated diabetes21–23. The effects of miR-375, miR-30a, and miR-34a have been examined in pancreatic islet cells under diabetic conditions, but their contributions to a spe- ...
Our data suggests that gga-miR-375 may function as a tumour suppressor thereby regulating cancer cell proliferation and it plays a key role in avian leukosis tumorigenesis. References [1] Payne LN, Howes K, Gillespie AM, Smith LM (1992) Host range of Rous sarcoma virus pseudotype RSV(HPRS-...
However, overexpression of miR-375 has also been observed in medullary thyroid carcinoma [30], breast cancer [31], and prostate cancer [32]. Functionally, miR-375 acts as a tumor suppressor that inhibits cell proliferation, migration, invasion, and tumor metastasis [21,28,29,33] by targeting...