目的探讨急性心肌梗死(AMI)患者血清长链非编码核糖核酸牛磺酸上调基因1(lncRNA TUG1)和微小核糖核酸370-3p(miR-370-3p)水平变化及意义。 方法选取122例AMI患者为AMI组,同期选择体检健康的志愿者122例为对照组,RT-qPCR法检测血清lncRNA TUG...
荧光素酶报告实验表明,miR-370-3p或miR-1296-5p上调降低了野生型TRIM14报告质粒的荧光素酶活性,但未降低TRIM14-370Mut或TRIM14-1296Mut载体的荧光素酶活性(图6A、B)。 此外,miR-370-3p或miR-1296-5p敲低后,CRC细胞中的TRIM...
目的:探讨miR-370-3p/Sestrin2(SESN2)调控脂多糖(lipopolysaccharide,LPS)诱导的小鼠肺泡上皮细胞(alveolar epithelial cells,AECs)凋亡的机制.方法:将C57BL/6J小鼠随机分为LPS+anti-NC组和LPS+miR-370-3p抑制剂(anti-miR-370-3p)组,每组12只.通过气管内注射LPS(5 mg/kg)来诱导急性肺损伤(acute lung injury,...
①观察骨肉瘤及癌旁组织miR -370-3p 及及其下游靶基因叉头框蛋白M1（FOXM1）mRNA 表达：37例骨肉瘤患者，均行肿瘤切除术，术中保存骨肉瘤及癌旁组织，采用实时定量PCR 法检测骨肉瘤及癌旁组织miR -370-3p 、FOXM1mRNA ，分析骨肉瘤组织FOXM1mRNA 表达与miR -370-3p 表达的相关性。采用Kaplan -Meier 曲线、...
the inhibition of miR-370-3p suppressed 3T3-L1 preadipocyte proliferation and promoted preadipocyte differentiation. In addition, Mknk1, a target gene of miR-370-3p, plays an opposing role in preadipocyte proliferation and differentiation. Moreover, consistent results from in vitro as well as in vi...
hsa-miR-370-3p agomir 是一种经过特殊化学修饰的miRNA模拟物,miRNA成熟链全链进行甲氧基修饰,在5'端和3'端分别有2个和4个硫代骨架修饰,并在3'端连接有高亲和性胆固醇修饰。miRNA agomir 可以模拟内源性miRNA,上调miRNA活性。与普通模拟物相比,miRNA agomir在动物实验中具有更高的稳定性和抑制效果,更易通过细胞...
英文名称:hsa-miR-370-3p mimic 品牌厂商性质产地货期价格 MedChemExpress (MCE)生产商美国现货￥960 性能特点 hsa-miR-370-3p mimic 是一种化学合成的miRNA模拟物,能模拟内源性miRNA,上调miRNA活性,用于功能获得性(gain-of-function)研究。 在线咨询
Thus, miR-370-3p overexpression reduced lipid accumulation. Conversely, the inhibition of miR-370-3p suppressed 3T3-L1 preadipocyte proliferation and promoted preadipocyte differentiation. In addition, Mknk1, a target gene of miR-370-3p, plays an opposing role in preadipocyte proliferation and ...
Our article is also a part of this research axis as it investigated the biomarker and/or therapeutic agent role that miRNA-370-3p might play in GBM. From our data, we can conclude that miR-370-3p is a therapeutic tool in anti-glioblastoma therapy but not an “in initial tumor” or ...