通过细胞实验发现,与对照相比较,转染MIR337-3p模拟物的靶细胞中,与VDR抗菌反应相关的效应分子CYP27B1、DEFB4A和CAMP的表达明显降低;反之,在转染MIR337-3p抑制剂的靶细胞中这些分子的表达明显增加,说明MIR337-3p可以广泛抑制与VDR通路相...
miR-337-3pBreast cancer (BC) is a common malignant tumor in women, and a considerable number of studies show that aberrant expression of miRNA is correlated with BC development. By analyzing TCGA-BRCA database through bioinformatics method, this study disclosed that miR-3373p was significantly ...
PIK3CA and PIK3CB were discovered to affect cell proliferation of EOC cells in combination, and only when overexpressed simultaneously in miR-337-3p-expressing cells, could fully restore cell proliferation. In vivo investigation confirmed that miR-337–3p is a tumor suppressor that control expression...
MCE 国际站:rno-miR-337-3p inhibitor 产品活性:rno-miR-337-3p inhibitor 是一种全链经过甲氧基修饰的成熟miRNA的互补单链。miRNA inhibitor通过特异性结合成熟miRNA,阻止miRNA与其靶基因的互补配对,从而抑制miRNA的功能,可用于miRNA 功能缺失性(loss-of-function)研究。 研究领域:Epigenetics 作用靶点:MicroRNA 相关...
货号:mml-miR-337-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:mml-miR-337-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
Conclusion We discovered a new function of miR-337-3p in regulating PCSK9 expression and LDL-C absorption, suggesting miR-337-3p might be a new therapeutic target for the development of antihyperlipidemic drug. 展开 关键词: Dual regulation Hyperlipidemia LDL-C PCSK9 miR-337-3p ...
miR-337-3p bound to the 3 '-untranslated region of Myo10 mRNA, thereby attenuating the translation of Myo10. Using loss-of-function and gain-of-function approaches, we found that circ-calm4 regulated cell proliferation by regulating the cell cycle. Additionally, we verified the functions of ...
Usingin vitroapproaches, we demonstrated that over-expression of the microRNA miR-337-3p sensitizes NCI-H1155 cells to paclitaxel, and that miR-337-3p mimic has a general effect on paclitaxel response in NSCLC cell lines, which may provide a novel adjuvant strategy to paclitaxel in the ...
MiR-337-3p has already been discovered to play regulatory roles in tumor proliferation and metastasis, adipocyte browning and ischemic brain injury, etc. However, the association between miR-337-3p and LDL-C is unknown. Methods Gene Expression Omnibus (GEO) dataset and two hyperlipidemic murine ...
MiR-337-3p regulated OA chondrocytes proliferation through PTEN/AKT axis and thus involved in OA. Introduction Osteoarthritis (OA) is a degenerative disease that damages the bone, synovial tissues and articular cartilage [1]. It commonly affects multiple bone and joint of human body, which again ...