通过细胞实验发现,与对照相比较,转染MIR337-3p模拟物的靶细胞中,与VDR抗菌反应相关的效应分子CYP27B1、DEFB4A和CAMP的表达明显降低;反之,在转染MIR337-3p抑制剂的靶细胞中这些分子的表达明显增加,说明MIR337-3p可以广泛抑制与VDR通路相...
miR-337-3p过表达方案在预防治疗肌腱病及韧带骨化或钙化病中的应用本发明提供miR3373p过表达方案在预防治疗肌腱病及韧带骨化或钙化病中的应用.本发明的miR3373p过表达方案在预防治疗肌腱病及韧带骨化或钙化病中的应用,能够抑制钙化肌腱基因表达,抑制肌腱及韧带组织钙化,并促进肌腱及韧带组织修复....
法律状态公告日法律状态法律状态信息 2019-08-27 实质审查的生效 实质审查的生效IPC(主分类):A61K 31/7088 2019-08-02 公开 公开 同族专利 1. 张晓玲, 耿倚云.miR-337-3p过表达方案在预防治疗肌腱病及韧带骨化或钙化病中的应用[P].A61K31/7088(2006.01)I:CN110075115A,2019-04-29.热门...
货号:mml-miR-337-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:mml-miR-337-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
MiR-337-3p has already been discovered to play regulatory roles in tumor proliferation and metastasis, adipocyte browning and ischemic brain injury, etc. However, the association between miR-337-3p and LDL-C is unknown. Methods Gene Expression Omnibus (GEO) dataset and two hyperlipidemic murine ...
明确miR-337-3p对PTEN的调控和对软骨细胞增殖的影响.结果:过表达miR-337-3p后OA软骨细胞密度增加.经MTT法检测细胞显示OA软骨细胞活力增强.流式细胞术检测显示OA软骨细胞停滞在G0/GI期,而miR-337-3p过表达解除了这种阻断作用,促进DNA复制及细胞增殖活性.OA软骨细胞凋亡率(10.75±1.38),过表达miR-337-3p后OA软骨...
MiR-337-3p regulated OA chondrocytes proliferation through PTEN/AKT axis and thus involved in OA. Introduction Osteoarthritis (OA) is a degenerative disease that damages the bone, synovial tissues and articular cartilage [1]. It commonly affects multiple bone and joint of human body, which again ...
We found that the expression of hsa-miR-134 and hsa-miR-337-3p was significantly less in metastatic lymph node tissues than in primary tumors of gastric cancer. Next, we investigated the effects of hsa-miR-134 or hsa-miR-337-3p on the inhibition of gastric cancer cell growth and invasion...
Usingin vitroapproaches, we demonstrated that over-expression of the microRNA miR-337-3p sensitizes NCI-H1155 cells to paclitaxel, and that miR-337-3p mimic has a general effect on paclitaxel response in NSCLC cell lines, which may provide a novel adjuvant strategy to paclitaxel in the ...
miR-337-3p bound to the 3 '-untranslated region of Myo10 mRNA, thereby attenuating the translation of Myo10. Using loss-of-function and gain-of-function approaches, we found that circ-calm4 regulated cell proliferation by regulating the cell cycle. Additionally, we verified the functions of ...