结直肠癌组织miR-331-3p、MLLT10_mRNA表达变化及其临床意义
结果与正常肝细胞株相比,miR-331-3p在肝癌细胞株中表达下调,且随着肝癌细胞株侵袭转移程度增加,其表达下调越明显(P<0.05);与正常肝组织相比,肝癌组织中miR-331-3p有不同程度的表达下调(P<0.05),且与肝癌患者肿瘤多发结节(P=0.036)、低分化程度(P=0.035)以及伴有静脉浸润(P=0.016)等临床病理特征相关。结论miR-...
western blot检测显示,分别用miR-331-3p或miR-9-5p 模拟物处理293T细胞时,SQSTM1或OPTN蛋白水平降低(Figure 3D-E)。因此,结果表明Sqstm1可能是miR-331-3p的靶点,Optn可能是miR-9-5p的靶点。 为了确定淀粉样斑块是否受到miR-331-3p和mi...
miRNA is a small class of endogenous non-coding RNA molecules that exist in eukaryotic cells.miR-331-3p is a member of miRNA family,which plays an important role in the physiological process.In recent years,effects of miR-331-3p on malignant tumors have been increased attention....
miRNA是一种存在于真核生物细胞中的一类内源性非编码的RNA小分子,miR-331-3p作为miRNA家族中的一员,在细胞生理过程中发挥重要作用.近年来,miR-331-3p在恶性肿瘤中的作用日益受到关注.已有研究显示,miR-331-3p在宫颈癌,肝癌,胶质母细胞瘤及前列腺癌等恶性肿瘤的发生发展及复发转移过程中均发挥着重要作用.这些研究...
货号:cgr-miR-331-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:cgr-miR-331-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
Inhibition of E2F1 by MiR-331-3p mimic promoted cell proliferation and migration in Bel-7402. These results demonstrated that MiR-331-3p down-regulated E2F1 to promote cell proliferation and migration in HCC. 展开 关键词: Molecular Role miR-331-3p Hepatocellular Carcinoma Bel-7402 E2F1 ...
Here, we show that epigenetic regulator PRMT5, which is modulated by the circSPON2/miR-331-3p axis, promotes the progression of PCa through inhibiting the transcription of CAMK2N1. The novel circSPON2/miR-331-3p/PRMT5/CAMK2N1 axis may serve as a promising therapeutic target of PCa. Mater...
Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy 3Comments pubmed: 33500732 doi: 10.7150/thno.47408 issn: 1838-7640 Meng-Lu Chen,Chun-Gu Hong,Tao Yue,Hong-Ming Li,Ran Duan,Wen-Bao Hu,Jia Cao,Zhen-Xing Wang,Chun-Yuan Chen,Xiong-Ke Hu,Ben ...
Recently, we demonstrated that microRNA-331-3p (miR-331-3p) down-regulates ERBB-2 expression in PCa cells (14). microRNAs (miRNAs) are a family of short, endogenous, non-coding RNAs that bind with imperfect complementarity to the 3′-untranslated region (3′-UTR) of specific target mRNAs...