目前的研究证实雷公藤甲素和miR-328-3p在体外和体内胶质瘤异种移植细胞中发挥着重要作用。miR-328-3p的上调可以通过抑制Akt/mTOR信号通路来抑制胶质瘤细胞的增殖和诱导凋亡,表明miR-328-3p是胶质瘤细胞中的肿瘤抑制miRNA。此外,雷公藤甲...
miR-328-3p对氧化型低密度脂蛋白诱导的冠状动脉内皮细胞损伤的保护作用及机制研究侯永兰李霞王建美刘振韩明磊刘烝昊金卫东Journal of Sichuan University (Medical Science Edition)
124-3p ㊁miR-328-3p ㊁miR-338-3p 可调节成骨㊁破骨引起PMOP ,可通过调控其表达干预PMOP 的发生和治疗㊂[关键词] 绝经后骨质疏松;miR-124-3p ;miR-328-3p ;miR-338-3p Expression of miR -124-3p ,miR -328-3p and miR -338-3p in bone tissue of postmenopausal osteo⁃ porosis ...
Guangrao County People's Hospital, Dongying City, Shandong Province 257300, People's Republic of China Background: MiR-519d and miR-328-3p had tumor-regulatory properties in different cancers, but their combinatorial effects and potential common target in breast cancer had not been fully reported....
本发明属于生物技术领域,涉及miR3283p在制备脑梗死及脑缺血再灌注预后预测试剂中的应用.本发明提出血清外泌体miR3283p在脑梗死及脑缺血再灌注预后预测和治疗中的应用,并通过具体试验结果进行了验证,为脑梗死及脑缺血再灌注预后预测试剂和试剂盒以及预后药物的研发提供新思路....
印记结果表明PINK1是miR-328-3 p的直接靶点.结论 结果证明,miR-328-3p在非小细胞肺癌患者中是一种肿瘤抑制因子,可能成为非小细胞肺癌患者的一个潜在的治疗靶点.%Objective MicroRNAs (miRNAs) have emerged as important regulators involved in malignant progression in some cancers.miR-328-3p has been found to...
基因实验验证miR-328-3p与FOXP3的靶向调控关系,蛋白质印迹法检测miR-328-3p mimics对Caco-2细胞中FOXP3蛋白表达的影响.将FOXP3过表达载体(pcDNA3.1-FOXP3)和miR-328-3p mimics共转染到Caco-2细胞,利用上述相同方法测定细胞侵袭,迁移和细胞MMP2,MMP9活性.结果 与结直肠上皮细胞比较,miR-328-3p在结直肠癌细胞...
此外,miR-328-3p显著抑制肺癌细胞A549以及H1299细胞的增殖,侵袭能力.此外,过表达miR-328-3p能够抑制A549以及H1299细胞中cyclinB1,cyclinD1蛋白的表达.荧光素酶活性检测以及免疫蛋白印记结果表明PINK1是miR-328-3p的直接靶点.结论结果证明,miR-328-3p在非小细胞肺癌患者中是一种肿瘤抑制因子,可能成为非小细胞肺癌患者...
Ma W, Ma C, Zhou N et al (2016) Up- regulation of miR-328-3p sensitizes non-small cell lung cancer to radiotherapy. Sci Rep 6:31651. doi:10.1038/srep31651Ma W, Ma CN, Zhou NN, Li XD, Zhang YJ. Up-regulation of miR-328-3p sensitizes non-small cell lung cancer to radiotherapy...
MiR-328–3p knockdown showed the opposite effects. In addition, we confirmed that miR-328–3p directly bound to 3′UTR of Girdin and negatively regulated its expression. Girdin knockdown or treatment with PI3K inhibitor LY294002 blocked the effects of miR-328–3p inhibitor on cell proliferation,...