目前的研究证实雷公藤甲素和miR-328-3p在体外和体内胶质瘤异种移植细胞中发挥着重要作用。miR-328-3p的上调可以通过抑制Akt/mTOR信号通路来抑制胶质瘤细胞的增殖和诱导凋亡,表明miR-328-3p是胶质瘤细胞中的肿瘤抑制miRNA。此外,雷公藤甲...
印记结果表明PINK1是miR-328-3 p的直接靶点.结论 结果证明,miR-328-3p在非小细胞肺癌患者中是一种肿瘤抑制因子,可能成为非小细胞肺癌患者的一个潜在的治疗靶点.%Objective MicroRNAs (miRNAs) have emerged as important regulators involved in malignant progression in some cancers.miR-328-3p has been found to...
124-3p ㊁miR-328-3p ㊁miR-338-3p 可调节成骨㊁破骨引起PMOP ,可通过调控其表达干预PMOP 的发生和治疗㊂[关键词] 绝经后骨质疏松;miR-124-3p ;miR-328-3p ;miR-338-3p Expression of miR -124-3p ,miR -328-3p and miR -338-3p in bone tissue of postmenopausal osteo⁃ porosis ...
结果 miR-328-3p 在脑胶质瘤细胞和组织中表达降低,其表达水平与原发性和复发性脑胶质瘤患者总 生存率呈正相关;miR-328-3p 与雷公藤甲素可以协同作用抑制脑胶质瘤细胞的生长,促进脑胶质瘤细胞的凋亡,抑制 Akt / mTOR 信号通路的激活. 结论 miR-328-3p 在脑胶质瘤细胞中起到抑癌基因的作用,雷公藤甲素可能...
MiR-328-3p was the most stable gene and we also investigated the effect of gene normalization, demonstrating that different normalization strategies have important implications for accurate data interpretation.doi:10.1038/s41598-019-56172-wMarcelle SanJuan Ganem Prado...
The expression level of miR-328-3p affects the radiosensitivity of osteosarcoma cells. (A) miR-328-3p expression levels were detected by qPCR in HOS and HOS-2R cells. HOS acted as controls, and radiation-tolerant HOS cell lines (HOS-2R) acted as IR (2 Gy) group which were established...
Guangrao County People's Hospital, Dongying City, Shandong Province 257300, People's Republic of China Background: MiR-519d and miR-328-3p had tumor-regulatory properties in different cancers, but their combinatorial effects and potential common target in breast cancer had not been fully reported....
摘要: MiR-328-3p has been reported to be downregulated and serve as a tumor suppressor in several cancers. Previous studies only have reported the downregulation of miR-328-3p in CRC. Ho... 查看全部>>关键词:Colorectal cancer Girdin Metastasis miR-328-3p PI3K/Akt ...
In conclusion, miR-328–3p may inhibit proliferation and metastasis of CRC cells by targeting Girdin and inactivating the PI3K/Akt signaling pathway. MiR-328–3p may be a novel target in cancer therapy. 展开 关键词: Colorectal cancer Girdin Metastasis PI3K/Akt miR-328–3p ...
货号:rno-miR-328a-3p 原价:￥2730 现价:￥2100.00节省:￥630 规格:1 kits 说明:rno-miR-328a-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转...