其中,miR-29a-5p和miR-222被认为对于肝癌具有重要的诊断和预后意义。 miR-29a-5p是一种肝癌细胞中下调的miRNA,与肝癌细胞的增殖、凋亡、侵袭和转移密切相关。研究发现,血清中miR-29a-5p水平显著降低,而且在肝癌患者中的表达水平低于非肝癌患者。当血清中miR-29a-5p水平过低时,提示肝癌的存在,并预示肝癌的预后较差...
本发明的研究结果表明miR29a5p及其类似物在体外能抑制神经干细胞的增殖(P<0.05),并促进神经干细胞分化为神经元(P<0.05).以上实验结果可为miR29a5p及其类似物用于制备促进神经干细胞向神经元定向分化的药物提供依据,为神经干细胞定向分化为神经元提供了新的方法,miR29a5p及其类似物有望成为治疗许多神经退行性疾病的...
货号:bfl-miR-29a-5p 原价:￥4030 现价:￥3098.38节省:￥932 规格:1 kits 说明:bfl-miR-29a-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录产...
对表达水平高于Ⅲ~Ⅳ期患者,血清m i R -425-5p 相对表达水平低于Ⅲ~Ⅳ期患者(P <0.05);中高分化子宫内膜癌患者血清m i R -125b ㊁m i R -29a 水平高于低分化患者,血清m i R -425-5p 表达水平低于低分化患者(P <0.05);淋巴结转移的子宫内膜癌患者m i R -125b ㊁m i R -29a 相对表达...
Figs 5a/c, "The apoptotic rate of Ishikawa cells is significantly enhanced after miR-29a-5p mimic and siTPX2 transfection compared to NC cells, as assessed by FCM ... The apoptotic rate of KLE cells is significantly enhanced after miR-29a-5p mimic and siTPX2 transfection compared to NC ...
miR-21-5p的上调可能与细胞凋亡信号通路的抑制和炎症调节有关,进而导致结核病发展。miR-21-5p的高表达可作为结核病的生物标志物,有助于早期诊断和疾病预后的评估。 miR-29a是miR-29家族的一个成员,其在炎症和纤维化中发挥关键作用。miR-29a的表达在结核病患者中被发现显著下调,这与结核病的病理进展和肺纤维化...
Klf-5 and IRF-1 binding sites or their mutant sequences were inserted into the pGL3-Basic vector. Sequences of the circErbB4, AT2R and QKI genes’ 3′UTR containing the miR-29a-5p target site or its mutant sequences were inserted into the pmirGLO Dual-Luciferase miRNA Target Expression ...
miR-764-5p promotes osteoblast differentiation through inhibition of CHIP/STUB1 expression 来自 EBSCO 喜欢 0 阅读量: 140 摘要: Differentiation of committed precursor cells into the osteoblast lineage is tightly regulated by several factors, including Runx2 and BMP2. We previously reported that C ...
Changes in EC-derived cell proliferation, invasion and apoptosis after exogenous miR-29a-5p and TPX2 over-expression and/or silencing were assessed using CCK-8 (cell counting kit-8), colony formation, Transwell and flow cytometry assays, respectively. We found that in primary EC tissues the ...
货号:gga-miR-29a-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:gga-miR-29a-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...