Further research shows miR-23a-5p can target PTEN and degrade it, causing activation of PI3K/Akt/mTOR/Snail pathway. lncRNA LOC102551149 can be used as a competition endogenous RNA (ceRNA) targeting miR-23a-5p through base pairing, and siRNA LOC102551149 or exogenous miR-23a-5p can induce ...
货号:mdo-miR-23a-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:mdo-miR-23a-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
HER2 mRNA expression. Strikingly, neratinib reversed the efficacy of CDK4/6 inhibitor and endocrine therapy by reducing HER2 mRNA stability in HR+/HER2-low breast cancer through the interaction of HER2 3’-UTR region with hsa-miR-23a-5p. Even after reducing neratinib dosage to the standard 1/...
The serum levels of miR-23a, miR-150, and miR-150-5p were significantly elevated in the DOP group compared to the non-DOP group (P < 0.05). Pearson correlation analysis revealed a negative association between the serum levels of miR-23a, miR-150, and miR-150-5p in diabetic patients ...
摘要 目的探讨胃癌组织微小核糖核酸(miR)-23a-3p、miR-361-5p表达与磷脂酰肌醇3激酶(PI3K)/蛋白激酶B(AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路和预后的关系。方法采用实时荧光定量聚合酶链反应...展开更多 Objective To investigate the relationship between the expression of microRNA(miR)-23a-3p and miR-...
5)外泌体miR-31-5p促进体内转移 我们假设来自HExo的外泌体miR-31-5p可以增加异种移植模型中LUAD细胞的转移能力。在静脉尾注射后的8周观察期内,我们取小鼠肺组织标本,用HE染色(图5a)。通过统计染色组织中转移性结节的数量,我们发现HExo组小鼠肺转移性...
1F是荧光素酶报告基因分析显示,miR-138-5p的过表达抑制KDM6B mRNA的3 ' -UTR驱动的荧光素酶活性,但不抑制突变的同源3 ' -UTR驱动的荧光素酶活性。 Part2miR-138-5p介导癌细胞诱导的巨噬细胞KDM6B表达抑制 2A是用miR-138-5p模拟...
miRNA-23a-5p (miR-23a-5p) is a novel miRNA, which promotes cell growth and survival in several types of cancer. The aim of the present study was to investigate the expression and functional significance of miR-23a-5p in bladder cancer. Microchip assays have shown that miR-23a-5p is ...
目的:探讨miR-23a-5p对大鼠脑缺血再灌注氧化应激反应的抑制作用.方法:应用qPCR技术检测大脑中动脉栓塞(middle cerebral artery occlusion,MCAO)SD大鼠模型中miR-23a-5p的表达水平.使用miR-23a-5p过表达慢病毒注射MCAO大鼠,设置假手术组,对照病毒组和miR-23a-5p病毒组.Berdron评分与2,3,5-三苯基氯化四氮唑(2,3,...
Downregulation of miR-23a-5p in leukemic cells leads to upregulation of protective autophagy by targeting TLR2 expression. Further, autophagy inhibitors when used as adjuvants along with conventional drugs can improve drug sensitivity in vitro as well in vivo in a mouse model of leukemia. Our ...