血清miR-202-3p,PS-PLA1水平单独时鉴别重度SLE的曲线下面积(AUC)分别为0.697,0.717,二者联合时鉴别重度SLE的AUC为0.903,血清miR-202-3p,PS-PLA1水平联合时鉴别重度SLE的AUC高于二者单独时(Z分别为4.417,3.311,P均<0.05).结论SLE患者血清miR-202-3p水平降低,血清PS-PLA1水平升高,并且二者与疾病活动度和细胞免疫...
直肠癌mir血浆microrna诊断抑制 中文摘要 第一部分血浆循环miRNA分析用于结直肠癌诊断的研究 研究目的 结直肠癌(CRC)是一种常见的消化系统恶性肿瘤,目前其仍缺乏有效的无 创性筛查手段,而微dxRNA(miRNA)已经明确与肿瘤的发生发展密切相关, 并且可以直接或间接的反映肿瘤阶段性变化,具有作为诊断标志物的潜在价值。 本...
复旦大学博士学位论文血浆microRNA用于结直肠癌诊断的研究及miR--202--3p抑制结直肠癌生长的机制研究姓名:***请学位级别:博士专业:肿瘤学指导教师:**2012-04-05中文摘要第一部分血浆循环miRNA分析用于结直肠癌诊断的研究研究目的结直肠癌(CRC)是一种常见的消化系统恶性肿瘤,目前其仍缺乏有效的无创性筛查手段,而微dx...
miR-202-3p水平比较:重度组>中度组>轻度组(P<0.05).Spearman相关性分析显示,抑郁症患者血清miR-211-5p水平与病情程度及认知功能损害呈负相关,miR-202-3p水平与病情程度及认知功能损害呈正相关(P<0.05).结论 抑郁症患者血清miR-211-5p低表达,miR-202-3p高表达,二者与病情程度及认知功能有关,有成为辅助抑郁症...
提取各组研究对象的精浆miRNA,采用实时定量PCR(qRT-PCR)法分析各组对象精浆miR-106b-5p和miR-202-3p的表达情况;采用受试者工作特征曲线(ROC)评价精浆miR-106b-5p和miR-202-3p对NOA的诊断价值.结果qRT-PCR检测结果显示,NOA组miR-106b-5p和miR-202-3p的表达水平显著低于对照组及弱精子症组(P<0.05),而弱...
目的探讨TRIM11靶向调控miR-24-3p对乳腺癌细胞增殖和侵袭的影响,明确TRIM11高表达与乳腺癌预后的相关性.方法免疫组化法检测TRIM11在31例乳腺癌和31例癌旁正常组织中的表达.用siRNATRIM11和miR-24-3p慢病毒转染人乳腺癌MCF7细胞,实时荧光定量PCR(RT-qPCR)和Westernbolt检测TR
MiR-202-3pMatrix metalloproteinase 1Interleukin-1 betaType II collagenMicroRNAs (miRNAs), small noncoding RNA molecules, have emerged as important factors during intervertebral disc degeneration. This study was to determine whether miR-202-3p regulates interleukin-1β (IL-1β)–induced expression of ...
miR-202-3pCalm1InflammationAcute respiratory distress syndrome (ARDS) is regarded as a type of respiratory failure. Emerging evidence has demonstrated the significant roles of microRNAs in various disorders. Nevertheless, the role of miR-202-3p in ARDS is unclear. Forty male C57BL/6 mice treated...
Hsa-miR-202-3p, up-regulated in type 1 gastric neuroendocrine neoplasms, may target DUSP1 microRNAtype1g-NENneuroendocrineneoplasmrecurrenceAIM To detect abnormal micro RNA(miRNA) expression in type 1 gastric neuroendocrine neoplasms(g-NENs) and find potential target genes.METHODS Tumour tissues from...
Collectively, miR-202-3p controls the proliferation, apoptosis, and synthesis function of human Sertoli cells via targeting LRP6 and Cyclin D1 of the Wnt/β-catenin signaling pathway. This study thus provides a novel insight into fate determinations of human Sertoli cells and niche of human ...