In comparison with control PC12 cells, OGD/R caused an increase in the level of miR-187-3p and a decrease in Seipin protein levels without changes in the level of Seipin mRNA. Using bioinformatics analysis, it was identified that miR-187-3p could bind to the CDS of Seipin. miR-187-3p...
Moreover, RTKN2 could be a direct target of miR-187-3p. In addition, knockdown of hsa_circRNA_104348 attenuated HCC tumorigenesis and lung metastasis in vivo. Taken together, these findings indicated that circular RNA hsa_circRNA_104348 might function as a competing endogenous RNA (ceRNA) to ...
目的研究微RNA-363-3p(miR-363-3p)在子宫内膜异位症(endometriosis,EMs)患者在位内膜(eutopic endometria,Eu)及异位内膜(ectopic endometria,Ec)中的表达并探究miR-363-3p对人子宫内膜间质细胞(endometrial stroma cells,EnSCs)生物学表型的影响.方法选择2017年10月-2018年10月在本中心妇产科行腹腔镜手术且术后经...
目的:本研究通过检测miR-424-3p在膀胱癌组织中的表达并分析其与膀胱癌患者临床病理参数的关系,同时通过体外细胞实验探讨miR-424-3p对膀胱癌细胞顺铂耐药性的影响以及相关机制,旨在明确miR-424-3p在膀胱癌细胞对顺铂耐药具体作用机制,为寻找新的膀胱癌治疗分子靶标,逆转膀胱癌顺铂耐药奠定理论和实验基础.方法:本研究选...
增殖凋亡免疫逃逸目的:研究环状RNA ras同源物基因家族成员T1(CircRHOT1)调节miR-187-3p/性别决定区Y框蛋白4(SOX4)轴对乳腺癌细胞增殖,凋亡和免疫逃逸的影响.方法:采用实时荧光定量PCR和Western blot检测体外培养的人正常乳腺上皮细胞MCF-10A和乳腺癌细胞MCF-7,Hs-578T,MDA-MB-231中CircRHOT1,miR-187-3p...
Multiple microRNAs (miRs) are dys-regulated during IR; among these miRs, miR-187-3p was recently reported to drive IL-1 beta release in retinal disease by activating members of the purinergic receptor family. However, the roles of miR-187-3p in the spinal cord are unclear. Thus, we ...
目的探讨miR-187-3p对破骨细胞增殖,凋亡,分化的影响及其对叉头框转录因子(FOX)K1/核因子(NF)-κB信号通路的调控作用.方法选取49例骨质疏松(OP)患者为OP组,同时选取绝经后骨质疏松性无骨折患者49例为control组;18只SPF级雌性大鼠,分为正常组与模型组,每组9只;原代分离培养OP大鼠破骨细胞,miR-NC,miR-187-3p ...
We demonstrate that miR-483-5p/3p acts together to target two pro-fibrosis factors, platelet-derived growth factor-β and tissue inhibitor of metalloproteinase 2, which suppress the activation of hepatic stellate cells (HSC) LX-2. Our work identifies the pathway that regulates liver fibrosis by ...
Multiple microRNAs (miRs) are dysregulated during IR; among these miRs, miR-187-3p was recently reported to drive IL-1β release in retinal disease by activating members of the purinergic receptor family. However, the roles of miR-187-3p in the spinal cord are unclear. Thus, we investigated...
miR-187-3pLRFN1BiomarkerTumor microenvironment (TME)Intra-tumoral heterogeneityClear cell renal cell carcinoma (ccRCC) is one of the most common malignant genitourinary cancers with high recurrence risk worldwide. Recently, multi-omics data facilitate obtaining a molecular landscape of tumor development,...