We analyzed the effects of miR-186-3p and insulin-like growth factor 1 (IGF1) on the proliferation, invasion, and apoptosis of cervical cancer cells in vitro by regulating the PI3K/Akt signaling pathway. In cervical cancer tissues and cells, miR-186-3p was downregulated, and IGF1 was up...
答:研究组的miR-19a-3p表达明显高于对照组,并且miR-19a-3p在结直肠癌(CRC)患者血清中高表达0.001; B:研究组的FOXF2(FOXF2)表达明显低于对照组,并且FOXF2在大肠癌患者中表达较低0.001; C:miR-19a-3p曲线下面积为0.883;D:FOXF2曲线...
H19能显著逆转miR-29b-3p inhibitor对细胞增殖,Ki-67表达,划痕闭合率,侵袭细胞数及VEGF,MMP-2,MMP-9表达的影响.体内实验发现,si-H19能显著逆转miR-29b-3p inhibitor对移植瘤生长,荷瘤裸鼠存活率,细胞凋亡率,Ki-67和VEGF表达的影响.结论 H19通过靶向miR-29b-3p提高卵巢癌细胞运动能力,降低荷瘤裸鼠的生存能力...
目的 观察肺浸润性腺癌组织中微小RNA-153-3p(microRNA-153-3p,miR-153-3p)和正性调控域锌指蛋白(positive regulatory domain zinc finger protein,PRDM2)的表达,分析其关联性及临床意义.方法 选择56例肺浸润性腺癌患者作为研究对象,留取术后肿瘤组织作为观察组,留取正常肺组织作为作为对照组.应用实时荧光定量PCR(...
We analyzed the effects of miR-186-3p and insulin-like growth factor 1 (IGF1) on the proliferation, invasion, and apoptosis of cervical cancer cells in vitro by regulating the PI3K/Akt signaling pathway. In cervical cancer tissues and cells, miR-186-3p was downregulated, and IGF1 was up...
LINC00460miR-186-3pMYCCD47PD-L1Long non-coding RNAs (LncRNAs) have been implicated as critical regulators of cancer tumorigenesis and progression. However, their functions and molecular mechanisms in colorectal cancer (CRC) still remain to be further elucidated.LINC00460 was identified by differential...
miR-186-3p调控MCM2宫颈癌侵袭目的 探讨miR-18 6-3p通过靶向调控微染色体维持复合物组分2(MCM2)对宫颈癌发生的作用机制.方法 选取2019年9月至2021年3月在石家庄市妇幼保健院确诊的宫颈癌患者60例,收集其宫颈癌组织及相应正常组织.采用RT-q PCR检测患者宫颈癌,癌旁正常组织标本以及人宫颈癌细胞中miR...
Moreover, miR-186-3p can be targeted to inhibit the IGF1R expression and prevent the activation of the IGF1R – P-PI3K – P-AKT pathway, thus increasing the apoptosis of dopaminergic neurons by regulating the cytochrome c – Bax – cleaved caspase-3 pathway. Our research showed that the ...
Kim SY, Lee YH, Bae YS (2012) MiR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells. Biochem Biophys Res Commun 429: 173-179. doi: 10.1016/j.bbrc.2012.10.117 PMID: ...
S. (2012). miR-186, miR-216b, miR-337-3p, and miR-760 cooperatively induce cellular senescence by targeting alpha subunit of protein kinase CKII in human colorectal cancer cells. Biochem. Biophys. Res. Commun. 429, 173-179. doi: 10.1016/j.bbrc.2012.10.117...