miR-151a and its host gene, focal adhesion kinase, FAK, are located in a region of chromosome 8q that is frequently amplified in solid tumors, including lung cancer. Lung cancer is the leading cause of cancer deaths worldwide and metastasis remains the major challenge in battling lung cancer...
研究mir-151a-5p对肺癌细胞的增殖,迁移,侵袭能力以及化疗敏感性的影响,为肺癌治疗提供新的依据.方法:将实验分为inhibitor转染组和NC对照组,用CCK-8实验检测转染inhibitor后A549细胞的增殖能力,Transwell迁移侵袭实验分别检测mir-151a-5P-inhibitor A549细胞的迁移,侵袭能力,然后应用Western blot检测inhibitor转染后EMT相关...
目的:探讨狼疮性肾炎(LN)患儿外周血单个核细胞(PBMC)miR-151a-3p的表达及其与疾病活动度和血管损害的相关性.方法:选取2016年1月至2019年3月海南省妇女儿童医学中心收治的LN患儿87例,其中Ⅱ型16例,Ⅲ型14例,Ⅳ型34例,Ⅴ型17例,Ⅵ型6例;另选取健康体检儿童40例作为健康对照组.采用系统性红斑狼疮病情活动指数(...
www.nature.com/scientificreports OPEN received: 27 March 2015 accepted: 04 November 2015 Published: 02 December 2015 Mitochondria-related miR-151a-5p reduces cellular ATP production by targeting CYTB in asthenozoospermia Ran Zhou1,2,*, Rong Wang3,*, Yufeng Qin1,2,*, Juan Ji1,2...
目的 分析急性脑梗死(ACI)患者血清miR-151a-3p和miR-210的表达及其与炎性因子的关系,并分析其临床意义.方法 选择2015年3月—2018年2月在新疆医科大学附属中医医院诊治的ACI患者160例作为观察组,患者脑梗死体积<5 cm3者79例为轻度组,5～15 cm3者35例为中度组,>15 cm3者46例为重度组.另选同...
细胞克隆形成检测及细胞周期检测结果证明,在结肠癌组织及SW480细胞中,miR-151a-3p的表达可以抑制结肠癌细胞增殖,降低CC成瘤能力;visfatin的表达可以促进CC的增殖;miR-151a-3p通过抑制靶基因visfat in的表达进而抑制结肠癌细胞活性和增殖,可能促进细胞凋亡.促miR-151a-3p表达类药物和visfatin抑制剂可能成为结肠癌药物...
与SCI+LV-NC组相比,SCI+LV-miR-186-5p组脊髓损伤区域减少,iNOS/IBA-1比例降低(P<0.05),TNF-α和IL-6水平降低(P<0.05),Bax蛋白表达下调(P<0.05),Bcl-2,HO-1和SOD-1蛋白表达上调(P<0.05),GFAP和IBA-1的阳性染色比例降低(P<0.05),HMGB1和TLR4的蛋白水平及NF-κB p65的磷酸化水平降低(P<0.05),BBB...
MIR-151A-3P AS AN UNIVERSAL ENDOGENOUS CONTROL FOR EXOSOME CARGO NORMALIZATIONThe present invention responds to the need to provide an endogenous miRNA for quantifying the amount of one or more targets miRNA in exosomes using normalization, that that does not vary within the different tumor types ...
In conclusion, our findings suggested that miR-151a-3p contributed to the pathogenesis of postmenopausal osteoporosis, and promoted its progress by targeting SOCS5 and activating JAK2/STAT3 signaling. Thus, anti-miR-151a-3p could be a potential therapeutic strategy for postmenopausal osteoporosis....
急性脑梗死miR-151a-3p基质金属蛋白酶-9超敏C反应蛋白目的 探讨急性脑梗死(acute cerebral infarction,ACI)患者的血清微小RNA(MicroRNA,miR)-151a-3p,基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9),超敏C反应蛋白(high sensitivity C reactive protein,hs-CRP)变化特点及其与病情间的相关性.方法 选取我院...