其发生机制与高糖皮质激素(而非咖啡因)通过编程亲代精子miR-142-3p高甲基化介导PPCE所致雄性子代大鼠肝脏脂代谢紊乱及代谢性炎症活化有关,并首次提出miR-142-3p是一个关键的脂代谢调节分子,可作为父源性NASH发生的早期干预靶标。 ...
mir-142在乳腺癌组织和细胞中的表达变化及其对mda-mb-231细胞侵袭迁移能力的影响 研究背景与意义 乳腺癌是全球女性最常见的恶性肿瘤之一，其侵袭和迁移是导致患者预后不良的重要因素。微小RNA（miRNA）在肿瘤发生发展过程中发挥关键调控作用，mir-142作为miRNA家族成员，研究其在乳腺癌组织和细胞中的表达变化，以及对mda...
此外,M-miR-142 与 TKI 和 PD-1 抗体联合使用,可增强抗白血病活性,显著延长小鼠生存期。 研究结论和讨论部分指出,该研究揭示了 CML 急变期免疫逃逸的新机制,即获得性 miR-142 缺失导致 T 细胞丢失,从而使 BC 期肿瘤细胞实现免疫逃逸。IL-6 在这一过程中起重要作用,它通过下调 miR-142,影响 T 细胞分化和...
结果PHC组血清中miR-142-3p(0.79±0.21)、miR-493-5p表达水平(0.83±0.22)显著低于良性组[(0.89±0.11)、(0.92±0.10)]和对照组[(1.01±0.12)、(1.02±0.13)],差异有统计学意义(P<0.05);PHC患者血清中miR-142-3p、miR-49...
The mechanisms underlying the transformation of chronic myeloid leukemia (CML) from chronic phase (CP) to blast crisis (BC) are not fully elucidated. Here, we show lower levels of miR-142 in CD34+CD38− blasts from BC CML patients than in those from CP
miR-223 has crucial functions in myeloid lineage development. However, the function of miR-142 remains unclear. In this study, we found that both miR-142 and miR-223 attenuated the proliferation of hematopoietic cells, and that miR-223 up-regulated miR-142 expression through the LMO2-L/-S ...
miR-142-3p
The study revealed that miR-142-3p expression was lower in drug-resistant cells compared parental cells. Higher miR-142-3p expression inhibited the viability, migration, and autophagic flux of drug-resistant cells, while promoting apoptosis and sensitivity to PTX treatment. Mechanistically, miR-142-...
miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities by Wilson Huang 1,†, Doru Paul 2, George A. Calin 1,3,4 and Recep Bayraktar 3,* 1 Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX ...
1、在CSCC进展过程中,miR-142-5p表达与淋巴细胞IDO表达相关,并与浸润的CD8+ T细胞数量负相关。 为了评估CSCC进展过程中miR-142-5p表达,作者使用ISH分析了116个病人的组织微阵列,与早期组织相比,miR-142-5p的表达和癌周的IDO阳性LV的比例都在晚期组织中显著上调,但是CD8+ T细胞数量在CRCC进展中减少了。因此,miR-...