The miR-126a-5p and VEGF mRNA of rat intervertebral disc tissue were detected by real-time fluorescence quantitative polymerase chain reaction (RT-PCR). The expression of VEGF protein of rat intervertebral disc tissue was detected by Western blot assay. Results Compared with the s...
P <0.05)㊂与SEP 组相比,SEP +IR 肺组织的W /D 减低,肺泡孔径增大,miR126a⁃5p 和miR155⁃5p 以及蛋白Caspase 1和Caspase 3表达量降低,同时可进一步抑制炎症因子IL⁃6和TNF⁃α的增加(P <0.05)㊂结论:Vit C 具有减轻肺水肿和稳定肺泡体积的作用,可能与miR126a⁃5p 和miR155⁃5p 诱导的...
The relative expression of miR-126a-5p in RPMECs increased when they were exposed to hypoxia (Po0.05), consistent with the microarray results. Pecam1 expression decreased, whereas alpha-smooth muscle actin (α-SMA) increased in the hypoxic RPMECs. Knockdown of miR-126a-5p in RPMECs followed...
miR-126a-5p在CD4本发明属于细胞工程和基因工程技术领域,具体涉及miR126a5p在CD4朱明星杜先才徐士梅赵殷奇杨继辉杨慧赵巍
A dual luciferase assay was used to verify the regulatory relationship between miR-126a-5p and ADAMTS-4. H1N1 influenza virus reduced fibroblast viability, inhibited miR-126a-5p expression, and promoted ADAMTS-4 expression. Overexpression of miR-126a-5p attenuated the cellular inflammatory response,...
miR-126a-5p在CD4本发明属于细胞工程和基因工程技术领域,具体涉及miR126a5p在CD4 朱明星杜先才徐士梅赵殷奇杨继辉杨慧赵巍
miR-126a-5ppersistent pulmonary hypertension of the newbornPersistent pulmonary hypertension of the newborn (PPHN) is a clinical syndrome characterized by increased medial and adventitial thickness of the lung vasculature. The underlying mechanisms that regulate the cell phenotype alteration during PPHN ...
血清miR-551-5p与TNF-α,IL-6,AMS,LPS水平,Ranson及APCHEⅡ评分呈正相关(r值依次为0.755,0.684,0.531,0.519,0.712,0.679,均P<0.05);血清miR-126a-5p与IL-6,IL-18,AMS水平及Ranson评分呈正相关(r值依次为0.711,0.678,0.628,0.701,均P<0.05);血清miR-551-5p,miR-126a-5p诊断SAP的ROC曲线下面积(AUC)...
miR-378-3p). Although they were all expressed at significantly lower levels in the heart compared to non-diabetic controls, only six miRNAs (miR-21-5p, miR-30d-5p, miR-126a-5p, miR-206-3p, miR-320-3p and miR-378-3p) were also reduced in exosomal content, while one miRNA (miR-...
本发明涉及miR6683p作为肾纤维化诊断标志的应用,以及miR6683p作为肾血管性高血压的应用;还涉及一种用于诊断肾纤维化的试剂盒,包括用于检测miR6683p表达量的检测剂.通过使用本发明提出的外周血中的miR6683p表达量作为分子标志,可对肾血管性高血压及其引起的肾脏纤维化损伤进行无创检测,并且对其病变过程进行无创动态监控...