mir-1247-3p 相关蛋白mir12473p是一种微小RNA(miRNA),它被预测为人类基因组中的一个miRNA基因。miRNA是一类重要的调控分子,它们通过与靶基因的mRNA结合,抑制靶基因的翻译或降解靶基因的mRNA,从而影响基因表达和细胞功能。目前还没有报道mir12473p的具体靶基因和生物学功能。因此,mir12473p相关蛋白的功能和生物学意义...
miR-1247-3p增殖活化TGF-β1目的探讨miR-1247-3p对肝纤维化的影响,分析其对肝星状细胞增殖与活化的作用及分子机制.方法四氯化碳(CCl_(4))制备肝纤维化大鼠模型,并分离大鼠原代肝星状细胞.慢病毒转染处理细胞,分为空白对照组,miR-1247-3p mimic组和miR-1247-3p inhibitor组.检测miR-1247-3p,转化生长因子-β1...
【学术交流讲座】肿瘤来源的外泌体 miR-1247-3p 诱导癌症相关的成纤维细胞活化以促进肝癌的肺转移.发布时间:2021/9/13 15:56:08 浏览次数:1738次 https://pubmed.ncbi.nlm.nih.gov/29335551/ 上一条:【学术交流讲座】BRD7通过负调节YB1诱导的上皮间质转化来抑制乳腺癌的侵袭和转移.下一条:【学术交流讲座...
miR12473p表达.结果延龄草苷降低了高糖诱导的HRVEC中ROS和MDA水平,凋亡率及Bax蛋白表达(P<0.05),提高了SOD活性,Bcl2蛋白表达及miR12473p表达(P<0.05),且呈剂量依赖性.过表达miR12473p降低了高糖诱导的HRVEC中ROS和MDA水平,凋亡率和Bax蛋白表达(P<0.05),提高了SOD活性和Bcl2蛋白表达(P<0.05).抑制miR12473p...
miR-1247-3p that directly targets B4GALT3, leading to activation of β1-integrin–NF-κB signaling in fibroblasts. Activated CAFs further promote cancer progression by secreting pro-inflammatory cytokines, including IL-6 and IL-8. Clinical data show high serum exosomal miR-1247-3p levels ...
miR-1247-3p表达水平升高,p-PI3K,p-Akt蛋白表达水平降低(P<0.05).不同浓度薄荷脑处理及miR-1247-3p低表达后,Cleaved-caspase-3表达水平及细胞凋亡率降低,TNF-α,IL-6,IL-1β水平降低(P<0.05).miR-1247-3p高表达逆转了薄荷脑对LPS诱导的AT-Ⅱ细胞凋亡,炎症反应及对p-PI3K,p-Akt表达水平的影响.结论:薄荷...
miR-1247-3pcolorectal cancer根據WHO的統計結果顯示,大腸直腸癌在全球癌症造成的死亡率中排名第三,由於早期大腸直腸癌並無症狀,直到癌細胞惡化或轉移後才會出現臨床表徵.治療上,主要以手術切除並以藥物治療,放射線治療為輔助;然而傳統化療藥物對於許多大腸直腸癌患者產生嚴重副作用,甚至在切除病灶後有復發的可能,因此...
The findings of the current study revealed a significant decrease in miR-1247-3p expression in CRC cells, especially those resistant to drugs. By contrast, there was a marked increase in the expression of cyclin D1 (CCND1), a known target gene of miR-1247-3p th...
FOXO1 was confirmed as a direct target of miR-1247-3p. Rescue assays suggested that the effect of miR-1247-3p inhibition on the viability, migration, and angiogenesis of HUVECs was partly abrogated by the knockdown of FOXO1. Our data suggest that miR-1247-3p is up-regulated in tumor-...
Given these findings, hsa-mir-1247-3p and/or its associated gene targets may offer a promising avenue to enhance patient survivability.Limbu, ShiwaniMcCloskey, Kara E.PLoS ONE