The expression levels of T-bet, GATA3, RORγt, and Foxp3 and the secreted levels of IFN-γ, IL-4, IL-17, and TGF-β respectively specific to Th1, Th2, Th17 and Treg, were assessed by qPCR and ELISA. Key findings Being transferred by AD-MSC-Exo, miR-10a was effectively induced ...
in inducible Treg cells. By simultaneously targeting the transcriptional repressor Bcl-6 and the corepressor Ncor2, miR-10a attenuated the phenotypic conversion of inducible Treg cells into follicular helper T cells. We also found that miR-10a limited differentiation into the TH17 subset of helper T...
Up-regulated miR-182 and down-regulated miR-10a expression in Th2- and Th1-Treg cells Treg cells confers suppressive capacity in vitro.Samir, Kelada